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Few studies have explored how personality disorder may influence pharmacological treatment outcomes. The aim of this study was to conduct a secondary analysis of data from a clinical trial of adjunctive nutraceutical treatments for bipolar depression, to determine whether maladaptive personality traits influence treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Scores on the Standardised Assessment of Personality \u2013 Abbreviated Scale screener were used to classify participants as having bipolar disorder with (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009119) and without (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200929) above threshold personality disorder symptoms (personality disorder). Outcome measures included: The Montgomery \u00c5sberg Depression Rating Scale, Clinical Global Impressions and Improvement Severity Scales, Patient Global Impressions\u2013Improvement scale, Bipolar Depression Rating Scale, Range of Impaired Functioning Tool, Social and Occupational Functioning Assessment Scale and Quality of Life and Enjoyment Scale (Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form). Generalised estimated equations examined the two-way interactions of personality disorder by time or treatment and investigated personality disorder as a non-specified predictor of outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over time, the Patient Global Impressions\u2013Improvement scores were significantly higher in those in the personality disorder group. No other significant differences in the two-way interactions of personality disorder by treatment group or personality disorder by time were found. Personality disorder was a significant but non-specific predictor of poorer outcomes on the Bipolar Depression Rating Scale, Range of Impaired Functioning Tool, and Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form, regardless of time or treatment group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the potential impact of maladaptive personality traits on treatment outcomes and suggests that the presence of comorbid personality disorder may confer additional burden and compromise treatment outcomes. This warrants further investigation as does the corroboration of these exploratory findings. This is important because understanding the impact of comorbid personality disorder on bipolar disorder may enable the development of effective psychological and pharmacotherapeutic options for personalised treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437231213558","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T03:42:43Z","timestamp":1700019763000},"page":"275-287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Influence of Personality Disorder Symptoms on Treatment Outcomes in Bipolar Disorder: A Secondary Analysis of a Randomised Controlled Trial: L\u2019influence des sympt\u00f4mes du trouble de la personnalit\u00e9 sur les r\u00e9sultats du traitement dans le trouble bipolaire : Une analyse secondaire d\u2019un essai randomis\u00e9 contr\u00f4l\u00e9"],"prefix":"10.1177","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9094-9515","authenticated-orcid":false,"given":"Alessandra","family":"Sarmiento","sequence":"first","affiliation":[{"name":"Deakin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"Dean","sequence":"additional","affiliation":[{"name":"Deakin University"},{"name":"Florey Institute for Neuroscience and Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-2775","authenticated-orcid":false,"given":"Bianca E.","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Deakin University"},{"name":"Deakin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Deakin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-6946","authenticated-orcid":false,"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"Deakin University"},{"name":"Florey Institute for Neuroscience and Mental Health"},{"name":"Orygen, Parkville, VIC, Australia"},{"name":"Centre for Youth Mental Health, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetal","family":"Dodd","sequence":"additional","affiliation":[{"name":"Deakin University"},{"name":"Centre for Youth Mental Health, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue M.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Orygen, Parkville, VIC, Australia"},{"name":"Centre for Youth Mental Health, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin S.","family":"Malhi","sequence":"additional","affiliation":[{"name":"Academic Department of Psychiatry, Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia"},{"name":"CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, NSW, Australia"},{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee H.","family":"Ng","sequence":"additional","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-2546","authenticated-orcid":false,"given":"Alyna","family":"Turner","sequence":"additional","affiliation":[{"name":"Deakin University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31544-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-47143-3_7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.2011.25.3.397"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199205)48:3<320::AID-JCLP2270480309>3.0.CO;2-F"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(90)90064-Y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(95)00024-H"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(91)90103-Y"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.2.232"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(96)02925-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.142.2.207"},{"issue":"1","key":"e_1_3_3_12_2","first-page":"1","article-title":"Comorbidity bipolar disorder and personality disorders","volume":"34","author":"Latalova K","year":"2013","unstructured":"Latalova K, Prasko J, Kamaradova D, Sedlackova J, Ociskova M. 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