{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:15:30Z","timestamp":1788671730307,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"T Chen Fong Fellowship in Medical Imaging Science"},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["27548"],"award-info":[{"award-number":["27548"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Campus Alberta Innovates Program Chair in Neurostimulation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Major depressive disorder (MDD) is associated with cognitive impairments that persist despite successful treatment. Transcranial magnetic stimulation is a noninvasive treatment for MDD that is associated with small procognitive effects on working memory and executive function. We hypothesized that pairing stimulation with N-methyl-D-aspartate (NMDA) receptor agonism would enhance the effects of stimulation and its procognitive effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      The effect of NMDA receptor agonism (D-cycloserine, 100 mg) on cognitive performance was tested in two randomized double-blind placebo-controlled trials: (1) acute effects of in the absence of stimulation (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u200920 healthy participants) and (2) a treatment study of individuals with MDD (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u200950) randomized to daily intermittent theta-burst stimulation (iTBS) with placebo or D-cycloserine for 2 weeks. Cognitive function was measured using the THINC-it battery, comprised of the Perceived Deficits Questionnaire, the Choice Reaction Time, the Trail Making Test, the Digit Symbol Substitution Test, and the 1-Back tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>D-cycloserine had no acute effect on cognition compared to placebo. iTBS\u2009+\u2009D-cycloserine was associated with significant improvements in subjective cognitive function and correct responses on the 1-Back when compared to iTBS\u2009+\u2009placebo. Improvements in subjective cognition paralleled depressive symptoms improvement, however 1-Back improvements were not attributable to improvement in depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>An intersectional strategy pairing iTBS with NMDA receptor agonism may restore cognitive function in MDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437241293984","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T09:36:02Z","timestamp":1730194562000},"page":"750-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Procognitive Effects of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation in Major Depressive Disorder: Effets procognitifs de la D-cyclos\u00e9rine en traitement compl\u00e9mentaire par la stimulation th\u00eata-burst intermittente dans le trouble d\u00e9pressif caract\u00e9ris\u00e9"],"prefix":"10.1177","volume":"70","author":[{"given":"Marilena M.","family":"DeMayo","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Calgary, Calgary, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"},{"name":"Mathison Centre for Mental Health Research and Education, Calgary, Canada"},{"name":"Department of Radiology, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeden","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Calgary, Calgary, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"},{"name":"Mathison Centre for Mental Health Research and Education, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myren N.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Calgary, Calgary, Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"},{"name":"Mathison Centre for Mental Health Research and Education, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe L.","family":"Bray","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"},{"name":"Mathison Centre for Mental Health Research and Education, Calgary, Canada"},{"name":"Department of Radiology, University of Calgary, Calgary, Canada"},{"name":"Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley D.","family":"Harris","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, Canada"},{"name":"Mathison Centre for 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