{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:08:28Z","timestamp":1793304508185,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023798","name":"Servier Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021138","name":"Lundbeck Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021138","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The genetic architecture of antidepressant response is poorly understood. This study investigated whether polygenic risk scores (PRSs) for major psychiatric disorders and a personality trait (neuroticism) are associated with antidepressant treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 148 participants with major depressive disorder (MDD) from the Canadian Biomarker Integration Network for Depression-1 (CAN-BIND-1) cohort. Participants initially received escitalopram (ESC) monotherapy for 8 weeks. Nonresponders at week 8 received augmentation with aripiprazole (ARI), while responders continued ESC until week 16. Primary outcomes were remission status and symptom improvement measured at weeks 8 and 16. At week 16, post-hoc stratified analyses were performed by treatment arm (ESC-only vs. ESC\u2009+\u2009ARI). Eleven PRSs derived from genome-wide association studies of psychiatric disorders (e.g., MDD and post-traumatic stress syndrome (PTSD)) and neuroticism, were analysed for associations with these outcomes using logistic and linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 8, a higher PRS for PTSD was nominally associated with a lower probability of remission (odds ratio (OR)\u2009=\u20090.08 [0.014\u20130.42], empirical\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009=\u20090.017) and reduced symptom improvement (beta (standard error)\u2009=\u2009\u221229.15 (9.76), empirical\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009=\u20090.019). Similarly, a higher PRS for MDD was nominally associated with decreased remission probability (OR\u2009=\u20090.38 [0.18\u20130.78], empirical\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009=\u20090.044). However, none of the results survived multiple testing corrections. At week 16, the stratified analysis for the ESC-only group revealed that a higher PRS for MDD was associated with increased remission probability (empirical\n                      <jats:italic>p-<\/jats:italic>\n                      value\u2009=\u20090.034) and greater symptom improvement (empirical\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009=\u20090.02). In contrast, higher PRSs for schizophrenia (empirical\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009=\u20090.013) and attention-deficit hyperactivity disorder (empirical\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009=\u20090.032) were associated with lower symptom improvement. No significant associations were observed in the ESC\u2009+\u2009ARI group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that PRSs may influence treatment outcomes, particularly in ESC monotherapy. Replication in larger studies is needed to validate these observations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437251329073","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T17:45:49Z","timestamp":1743270349000},"page":"552-564","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des r\u00e9sultats du traitement antid\u00e9presseur \u00e0 l\u2019aide des scores de risque polyg\u00e9niques : Rapport sur l\u2019\u00e9tude CAN-BIND-1"],"prefix":"10.1177","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-928X","authenticated-orcid":false,"given":"Leen","family":"Magarbeh","sequence":"first","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Pharmacology &amp; Toxicology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-312X","authenticated-orcid":false,"given":"Samar S. M.","family":"Elsheikh","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-0723","authenticated-orcid":false,"given":"Farhana","family":"Islam","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Pharmacology &amp; Toxicology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S.","family":"Marshe","sequence":"additional","affiliation":[{"name":"Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, 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