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Identifying predictors of relapse is, therefore, crucial for improving maintenance strategies and preventing future episodes. Remote data collection and sensing technologies may allow for more comprehensive and longitudinal assessment of potential predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Canadian Biomarker Integration Network in Depression Wellness Monitoring for MDD (CBN-WELL) study was a prospective, multicentre observational study with an aim to identify biomarkers associated with relapse in patients on maintenance treatment for MDD. Participants had a DSM-5-TR diagnosis of MDD in remission and a Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS) score \u226414. Participants remained on their baseline medication regimens and were followed bimonthly for up to 2 years. Relapse criteria included MADRS\u2009&gt;\u200922 for 2 consecutive weeks, suicidality or hospitalization, and initiation or change in medication for worsening symptoms. Data collection included clinical assessments, self-report questionnaires, and remote monitoring using wrist-worn actigraphs and smartphones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 96 participants had follow-up data. Of these, 28.9% experienced a depressive relapse during the study period, with an average time to relapse of 211 days. Baseline depressive severity, as measured by MADRS, was higher in participants who relapsed compared to those who did not, but few other baseline clinical measures differentiated these groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with MDD in remission continued to have high relapse rates despite maintenance treatment. The paucity of clinical factors that predict relapse underscores the need for biomarkers. The CBN-WELL database can be used for future research to integrate multiple predictive factors and to identify objective measures to predict relapse in individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437251337603","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T02:57:12Z","timestamp":1745981832000},"page":"565-573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study: Pr\u00e9dire la rechute d\u2019\u00e9pisodes d\u00e9pressifs pendant le traitement d\u2019entretien : Une \u00e9tude de suivi du bien-\u00eatre dans les troubles d\u00e9pressifs majeurs du R\u00e9seau canadien d\u2019int\u00e9gration des biomarqueurs pour la d\u00e9pression (CAN-BIND)"],"prefix":"10.1177","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-4669","authenticated-orcid":false,"given":"Raymond W.","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-4489","authenticated-orcid":false,"given":"Katerina","family":"Rnic","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1602-6382","authenticated-orcid":false,"given":"John-Jose","family":"Nunez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Ho","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0931-2855","authenticated-orcid":false,"given":"Joelle","family":"LeMoult","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Nunes","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Center for Depression Research and Clinical Care, UT Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-943X","authenticated-orcid":false,"given":"Benicio N.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-8994","authenticated-orcid":false,"given":"Kate L.","family":"Harkness","sequence":"additional","affiliation":[{"name":"Department of Psychology, Queen's University, Providence Care, Kingston, Canada"},{"name":"Department of Psychiatry, Queen's University, Kingston, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Hassel","sequence":"additional","affiliation":[{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-7185","authenticated-orcid":false,"given":"Sidney H.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-4535","authenticated-orcid":false,"given":"Qingqin S.","family":"Li","sequence":"additional","affiliation":[{"name":"Neuroscience, Janssen Research &amp; 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