{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:57:12Z","timestamp":1781657832580,"version":"3.54.5"},"reference-count":70,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Canada Brain Research Fund"},{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chagnon Family"},{"name":"CAMH Discovery Fund"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 183584"],"award-info":[{"award-number":["PJT 183584"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Changes in angiogenesis have been shown to contribute to cognitive decline and dementia. We aimed to identify angiogenesis blood markers associated with cognitive performance in older adults with mild cognitive impairment (MCI), remitted major depressive disorder (rMDD), or both (rMDD\u2009+\u2009MCI) who are at risk for dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We analyzed data from participants with MCI, rMDD, or rMDD\u2009+\u2009MCI in the Prevention of Alzheimer's Dementia with Cognitive Remediation plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression study. Elastic net regression was used to select variables associated with cognitive performance among 19 angiogenesis markers and 6 covariates. Linear regressions were used to determine which of the selected angiogenesis markers were associated with cognitive performance, controlling for the selected covariates. Significant angiogenesis markers were independently analyzed without other angiogenesis markers, controlling for covariates, with subgroup analyses in those with and without rMDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Angiogenin was the only selected marker associated with cognitive performance (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u20090.28,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009=\u20090.03,\n                      <jats:italic toggle=\"yes\">f<\/jats:italic>\n                      \u00b2\u2009=\u2009.02) when controlling for other selected markers (endothelial cell-specific molecule 1, e-selectin, interleukin-33 [IL-33], oncostatin M, platelet-derived growth factor-AB, IL-33 receptor, and tissue inhibitor of metalloproteinases-1) and selected covariates (age, education, apolipoprotein E \u03b54 status, diagnosis, and cardiovascular risk factors). When independently analyzed, angiogenin remained positively associated with cognitive performance (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=\u20090.21,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01,\n                      <jats:italic toggle=\"yes\">f<\/jats:italic>\n                      \u00b2\u2009=.02), controlling for the covariates. In subgroup analyses, angiogenin was also associated with cognition in rMDD and rMDD\u2009+\u2009MCI participants (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      \u2009=0.50, SE\u2009=\u20090.14,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic toggle=\"yes\">f<\/jats:italic>\n                      \u00b2\u2009=\u20090.08) and in MCI-only participants (\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      =\u20090.20, SE\u2009=\u20090.09\n                      <jats:italic toggle=\"yes\">,<\/jats:italic>\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02,\n                      <jats:italic toggle=\"yes\">f<\/jats:italic>\n                      \u00b2\u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The association of angiogenin with cognitive performance highlights a potentially novel biological pathway that could influence cognition in older adults at risk for dementia. Angiogenin may protect against cognitive decline, opening new avenues for innovative preventive, or therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437251337627","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:10:37Z","timestamp":1746051037000},"page":"519-530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l\u2019angiogen\u00e8se et cognition chez les personnes \u00e2g\u00e9es \u00e0 risque de d\u00e9mence"],"prefix":"10.1177","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-8564","authenticated-orcid":false,"given":"Bing Xin","family":"Song","sequence":"first","affiliation":[{"name":"University of Toronto"},{"name":"Sunnybrook Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Vieira","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute"},{"name":"University of Toronto"},{"name":"Sunnybrook Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno S.","family":"Diniz","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health"},{"name":"University of Connecticut Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"name":"St Michael's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair J.","family":"Flint","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"name":"University Health Network"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-6110","authenticated-orcid":false,"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"name":"Sunnybrook Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Mah","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"name":"Baycrest Health Sciences, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-6450","authenticated-orcid":false,"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health"},{"name":"University of Toronto"},{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek K.","family":"Rajji","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health"},{"name":"University of Toronto"},{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Ma","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-6637","authenticated-orcid":false,"given":"Krista L.","family":"Lanct\u00f4t","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"name":"Sunnybrook Research Institute"},{"name":"Centre for Addiction and Mental Health"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PACt-MD Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4406"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5385"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2024.01.225"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.60"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6065"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4602"},{"issue":"8","key":"e_1_3_3_9_2","article-title":"Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies","volume":"51","author":"Bai W","year":"2022","unstructured":"Bai W, Chen P, Cai H, et al. Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies. Age Ageing. 2022;51(8):afac173.","journal-title":"Age Ageing."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49853-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28140-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103693"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-021-00751-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.04.083"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.02.010"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191293"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.06.031"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97853-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200141"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.3241"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2006.2.3.213"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_3_3_24_2","volume-title":"Structured clinical interview for DSM-IV-TR Axis I disorders: patient edition","author":"First MB","year":"2005","unstructured":"First MB, Spitzer RL, Gibbon M, et al. Structured clinical interview for DSM-IV-TR Axis I disorders: patient edition. New York, NY: Biometrics Research Department, Columbia University; 2005."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03741.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.921312"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-203372"},{"issue":"1","key":"e_1_3_3_28_2","first-page":"324016","article-title":"Elevated angiopoietin-1 Serum levels in patients with Alzheimer\u2019s disease","volume":"2012","author":"Schreitm\u00fcller B","year":"2012","unstructured":"Schreitm\u00fcller B, Leyhe T, Stransky E, et al. Elevated angiopoietin-1 Serum levels in patients with Alzheimer\u2019s disease. Int J Alzheimer\u2019s Dis. 2012;2012(1):324016.","journal-title":"Int J Alzheimer\u2019s Dis"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02706-w"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000485245"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200058"},{"key":"e_1_3_3_32_2","first-page":"14733","article-title":"Increased serum e-selectin levels were associated with cognitive decline in patients with stroke","volume":"14","author":"Li J","year":"2021","unstructured":"Li J, Bao J, Gao C, et al. Increased serum e-selectin levels were associated with cognitive decline in patients with stroke. Int J Gen Med. 2021;14:14733\u201314739.","journal-title":"Int J Gen Med."},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00008"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2023.107773"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.12.003"},{"issue":"1","key":"e_1_3_3_36_2","article-title":"Converging mediators from immune and trophic pathways to identify Parkinson disease dementia","volume":"3","author":"Lue L-F","year":"2016","unstructured":"Lue L-F, Schmitz CT, Snyder NL, et al. Converging mediators from immune and trophic pathways to identify Parkinson disease dementia. Neurology\u00ae Neuroimmunol Neuroinflamma. 2016;3(1):e193.","journal-title":"Neurology\u00ae Neuroimmunol Neuroinflamma"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018004"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12974"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15369"},{"issue":"4","key":"e_1_3_3_40_2","first-page":"560","article-title":"Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function","volume":"72","author":"Tchalla AE","year":"2017","unstructured":"Tchalla AE, Wellenius GA, Sorond FA, et al. Elevated soluble vascular cell adhesion molecule-1 is associated with cerebrovascular resistance and cognitive function. J Gerontol: Ser A. 2017;72(4):560\u2013566.","journal-title":"J Gerontol: Ser A"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18042-1"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0458-5"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188709"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19120-0"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00112.2018"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1555115"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111922"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/138255890969483"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.210"},{"issue":"1","key":"e_1_3_3_50_2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025724","article-title":"Cardiovascular risk factors and risk of Alzheimer disease and mortality: a latent class approach","volume":"12","author":"Ruthirakuhan M","year":"2022","unstructured":"Ruthirakuhan M, Cogo-Moreira H, Swardfager W, et al. Cardiovascular risk factors and risk of Alzheimer disease and mortality: a latent class approach. J Am Heart Assoc: Cardiova Cerebrova Dis. 2022;12(1):e025724.","journal-title":"J Am Heart Assoc: Cardiova Cerebrova Dis"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2005.00503.x"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142409"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21136"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02456.x"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm488"},{"key":"e_1_3_3_57_2","first-page":"20181984718","article-title":"The potential of angiogenin as a Serum biomarker for diseases","volume":"2018","author":"Yu D","year":"2018","unstructured":"Yu D, Cai Y, Zhou W, et al. The potential of angiogenin as a Serum biomarker for diseases. System Rev Meta-Anal. Dis Markers. 2018;2018:20181984718.","journal-title":"System Rev Meta-Anal. Dis Markers"},{"key":"e_1_3_3_58_2","first-page":"10735","article-title":"Vascular endothelial growth factor and angiogenin in Alzheimer\u2019s disease","volume":"10","author":"Ragab OA","year":"2018","unstructured":"Ragab OA, Mohamed ES, Rashed KH, et al. Vascular endothelial growth factor and angiogenin in Alzheimer\u2019s disease. EC Neurology. 2018;10:10735\u201310740.","journal-title":"EC Neurology"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311906"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874205X01913010001"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt230"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050651"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00883-8"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317977"},{"key":"e_1_3_3_65_2","article-title":"Angiogenin in the neurogenic subventricular zone after stroke","volume":"12","author":"Gabriel-Salazar M","unstructured":"Gabriel-Salazar M, Lei T, Grayston A, et al. Angiogenin in the neurogenic subventricular zone after stroke. Front Neurol. 2021;12:662235. doi:https:\/\/doi.org\/10.3389\/fneur.2021.662235","journal-title":"Front Neurol"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm290"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0410-0"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.20"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130158"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30291-3"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13260"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437251337627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07067437251337627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437251337627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:47:15Z","timestamp":1781084835000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07067437251337627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/07067437251337627"],"URL":"https:\/\/doi.org\/10.1177\/07067437251337627","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}