{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:03:55Z","timestamp":1781089435318,"version":"3.54.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["Partial support from AT009198 (NCCIH\/NIH)"],"award-info":[{"award-number":["Partial support from AT009198 (NCCIH\/NIH)"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018836","name":"Alzheimer's Research and Prevention Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Older women with cardiovascular risk factors and subjective memory complaints are at greater risk for Alzheimer\u2019s disease (AD). We examined the changes in AD peripheral biomarkers, including phosphorylated-tau (p-tau), A\u03b240, A\u03b242, and A\u03b242\/40 ratio, in a randomized controlled trial of Kundalini yoga (KY) versus memory enhancement training (MET) in aging women at risk for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We recruited women (50+ years) with subjective memory complaints and high cardiovascular risk as defined by the ACC\/AHA Guideline on the Assessment of Cardiovascular Risk. Participants were randomized into KY versus MET, each lasting for 12 weeks, with a 24-week follow-up. We obtained blood samples at baseline and week 24 and measured A\u03b2 40, A\u03b2 42, and p-Tau. Participants completed the Memory Functioning Questionnaire (MFQ) to assess subjective memory at baseline and follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 79 patients (KY\u2009=\u200940; MET\u2009=\u200939) were randomized, and biomarker data were available for 56 participants (KY\u2009=\u200924; MET\u2009=\u200932) at baseline and the 24-week follow-up. There were no group differences in AD biomarkers at baseline or at 24-week follow-up, and there were no significant changes in AD biomarkers from baseline to 24-week follow-up. Higher baseline levels of A\u03b240 and A\u03b242 were significantly associated with an improvement in subjective memory (MFQ Frequency of Forgetting and Seriousness of Forgetting) at follow-up. There was no significant association of the A\u03b242\/40 ratio and p-tau with changes in subjective memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings indicate that peripheral A\u03b240 and A\u03b242 levels are associated with improvement in memory self-awareness, particularly the reported frequency and perceived severity of forgetting. These levels may serve as potential biomarkers, reflecting underlying biological effects that could be utilized in future assessments. Further research is needed to determine how to successfully utilize peripheral biomarkers and subjective memory complaints to identify at-risk populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary Title<\/jats:title>\n                    <jats:p>Peripheral Alzheimer\u2019s Disease biomarkers are related to change in subjective memory in older women in a trial of yoga vs. memory training.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437251343291","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T01:31:02Z","timestamp":1748655062000},"page":"542-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Peripheral Alzheimer's Disease Biomarkers Are Related to Change in Subjective Memory in Older Women with Cardiovascular Risk Factors in a Trial of Yoga vs. Memory Training: Lien \u00e9tabli entre les biomarqueurs p\u00e9riph\u00e9riques de la maladie d\u2019Alzheimer et l\u2019am\u00e9lioration de la m\u00e9moire subjective chez les femmes \u00e2g\u00e9es pr\u00e9sentant des facteurs de risque cardiovasculaire dans le cadre d\u2019un essai comparant le yoga \u00e0 l\u2019entra\u00eenement de la m\u00e9moire"],"prefix":"10.1177","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0419-3487","authenticated-orcid":false,"given":"Hanadi","family":"Ajam Oughli","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Siddarth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"},{"name":"Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meachelle","family":"Lum","sequence":"additional","affiliation":[{"name":"University of California Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Tang","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center\/New York Presbyterian Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Abikenari","sequence":"additional","affiliation":[{"name":"Stanford School of Medicine, Stanford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Cappelleti","sequence":"additional","affiliation":[{"name":"UCLA Immunogenetics Center, Department of Pathology &amp; Lab Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharma S.","family":"Khalsa","sequence":"additional","affiliation":[{"name":"Alzheimer's Research and Prevention Foundation, Tuscon, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lavretsky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA, USA"},{"name":"Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"issue":"16","key":"e_1_3_2_2_2","first-page":"1349","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. 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