{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:52:28Z","timestamp":1784325148511,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bowden Massey Strategic Research Initiative"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anticonvulsants are an essential treatment for bipolar disorder; however, there is relatively little known about their use in older age bipolar disorder (OABD). In this paper, which leverages a large international dataset, we aim to 1) describe the use of anticonvulsants in OABD compared to younger age bipolar disorder (YABD; ages &lt;50 years old) and 2) explore any demographic\/clinical correlates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A secondary analysis was conducted on the international data from the Global Aging and Geriatric Experiments in Bipolar Disorder project. The main objective was to report the prevalence of anticonvulsant use in OABD over 50 years old (mean age\u2009=\u200962.27) and the most prescribed anticonvulsant. Additional analysis explored any demographic and clinical correlates associated with anticonvulsant use. Generalized linear mixed models were used for this analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 2,691 participants with bipolar disorder who had anticonvulsant prescribing data, 34.4% (n\u2009=\u2009926) used anticonvulsants at the time of study. Rates of anticonvulsant prescribing did not significantly differ between OABD and YABD groups (36.7% (n\u2009=\u2009666) vs. 29.7% (n\u2009=\u2009260)). Anticonvulsant prescribing patterns for OABD and YABD did not significantly differ, with valproate as the most prescribed anticonvulsant. OABD anticonvulsant users had less lithium use, more antidepressant use, more rapid cycling, more mood episodes and more cardiovascular comorbidities compared to nonusers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anticonvulsant use was similar in OABD and YABD. A number of important clinical correlates of anticonvulsant use were identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437251372190","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:35:23Z","timestamp":1758602123000},"page":"489-497","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d\u2019anticonvulsivants pour le traitement des troubles bipolaires du sujet \u00e2g\u00e9 aupr\u00e8s d\u2019un \u00e9chantillon mondial provenant du projet GAGE-BD"],"prefix":"10.1177","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-8459","authenticated-orcid":false,"given":"Katie C.","family":"Bodenstein","sequence":"first","affiliation":[{"name":"McGill University, Jewish General Hospital\/Lady Davis Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Lesage","sequence":"additional","affiliation":[{"name":"McGill University, Jewish General Hospital\/Lady Davis Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Lavin","sequence":"additional","affiliation":[{"name":"McGill University, Jewish General Hospital\/Lady Davis Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigfried","family":"Schouws","sequence":"additional","affiliation":[{"name":"GGZ inGeest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis","family":"Orhan","sequence":"additional","affiliation":[{"name":"Institute of Psychology, Leiden University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Beunders","sequence":"additional","affiliation":[{"name":"GGZ inGeest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Institute for Health Research of the"},{"name":"Medical School of the University of Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursat","family":"Altinbas","sequence":"additional","affiliation":[{"name":"Atlas University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicent","family":"Balanz\u00e1-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"University of Valencia, CIBERSAM, INCLIVA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela G.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Mental Health Department, Medicine School, Minas Gerais University, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary P.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Yale School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farren B.S.","family":"Briggs","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia V.","family":"Calkin","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes V.","family":"Forlenza","sequence":"additional","affiliation":[{"name":"HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Forester","sequence":"additional","affiliation":[{"name":"Tufts Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel G.","family":"Gildengers","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno C.M.","family":"Haarman","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Hajek","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beny","family":"Lafer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula V.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-6450","authenticated-orcid":false,"given":"Benoit","family":"Mulsant","sequence":"additional","affiliation":[{"name":"University of Toronto, Center for Addiction & Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-9886","authenticated-orcid":false,"given":"Andrew T.","family":"Olagunju","sequence":"additional","affiliation":[{"name":"McMaster University\/St Joseph's Healthcare Hamilton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan E.","family":"Patrick","sequence":"additional","affiliation":[{"name":"McLean Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joquim","family":"Radua","sequence":"additional","affiliation":[{"name":"IDIBAPS, CIBERSAM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee","family":"Sarna","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Simhandl","sequence":"additional","affiliation":[{"name":"Medical Faculty, Bipolar Center Wiener Neustadt, Sigmund Freud University Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jair C.","family":"Soares","sequence":"additional","affiliation":[{"name":"University of Texas\/McGovern Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley N.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"University of California San Diego"},{"name":"Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Fiorelli","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangying","family":"Tsai","sequence":"additional","affiliation":[{"name":"Taipei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Yala","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Eyler","sequence":"additional","affiliation":[{"name":"University of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek","family":"Dols","sequence":"additional","affiliation":[{"name":"UMC Utrecht Brain Center, University Medical Center Utrecht"},{"name":"Department of Psychiatry, Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Sajatovic","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine"},{"name":"University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Rej","sequence":"additional","affiliation":[{"name":"McGill University, Jewish General Hospital\/Lady Davis Institute"},{"name":"Queen's University Belfast"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61611-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4534"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7396.960"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12714"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01145-w"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19091000"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1088001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181bf9ebd"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12795"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12331"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.09.003"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.01.051"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1388"},{"key":"e_1_3_2_17_2","unstructured":"The CES-D Scale: A Self-Report Depression Scale for Research in the General Population - Lenore Sawyer Radloff 1977 [Internet]. [cited 2024 Oct 16]. Available from: https:\/\/journals-sagepub-com.proxy3.library.mcgill.ca\/doi\/10.1177\/014662167700100306"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.06.074"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4635"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610215002380"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.15050657"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1013"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/104012371102300107"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.10.006"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000208"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.02.022"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2024.06.005"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437251372190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07067437251372190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07067437251372190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:47:30Z","timestamp":1781084850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07067437251372190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/07067437251372190"],"URL":"https:\/\/doi.org\/10.1177\/07067437251372190","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,22]]}}}