{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:30:06Z","timestamp":1792114206538,"version":"4.4.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","award":["(15T-009)"],"award-info":[{"award-number":["(15T-009)"]}],"id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The gut microbiome has been proposed as a potential modifiable target to treat mental illness. This double-blind randomized control trial investigated fecal microbiota transplant (FMT) in bipolar disorder (BD) to assess efficacy, safety, and feasibility. The primary outcome evaluated the effectiveness of standard approved therapy for BD depression\u2009+\u2009FMT in individuals not responding to standard treatment, measured by change in the Montgomery-\u00c5sberg Depression Rating Scale (MADRS) score from baseline to week 24. Secondary outcomes included FMT's impact on anxiety, global function, side-effects, and safety. The feasibility of this novel intervention was also assessed. Microbial analysis utilized whole-genome shotgun metagenomic sequencing, comparing outcomes between allogenic (donor) and autologous (participants own) FMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 35 participants (28 women and 7 men) with at least moderate depressive-phase BD (MADRS) were randomized to receive either allogenic FMT (n\u2009=\u200917) or autologous FMT (n\u2009=\u200918) via colonoscopy and were followed for 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MADRS scores significantly improved from baseline to the last visit in both treatment arms. There was no significant difference between allogenic FMT (16.74-point improvement) and autologous FMT (15.4-point improvement) regarding clinical efficacy (t\u2009=\u2009\u22120.47, p-value\u2009=\u2009.64, 95% confidence interval [CI]\u2009=\u2009\u22127.3\u20134.6). Microbiota analysis showed that allogenic FMT let to a bacterial profile similar to the healthy donor and increased bacterial diversity at the 6-month mark, whereas those receiving autologous FMT did not. The intervention was well tolerated with no significant adverse events. Recruitment, randomization, and retention metrics support feasibility of a larger trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Feasibility and tolerability data indicate further investigation into microbial manipulation in BD is warranted. The absence of efficacy differences between the two types of FMT, despite microbial change, highlights the importance of a true placebo in future studies, as well as the importance of understanding exactly what bacteria are linked to improvements. ClinicalTrials.gov, NCT0327922<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary Title<\/jats:title>\n                    <jats:p>Results of a Double-Blind Randomized Control Trial Investigating Fecal Microbiota Transplant (FMT) as an Add-on Treatment for Depression in Bipolar Disorder and Analyzing Microbial Diversity Changes Over 24 Weeks<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07067437261420877","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:31:24Z","timestamp":1773243084000},"page":"675-690","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Safety, Efficacy, and Feasibility of Fecal Microbiota Transplantation in a Population With Bipolar Disorder During Depressive Episodes: A Pilot Parallel Arm Randomized Controlled Trial: S\u00e9curit\u00e9, efficacit\u00e9 et faisabilit\u00e9 de la transplantation de microbiote f\u00e9cal chez une population atteinte de troubles bipolaires, au cours d\u2019\u00e9pisodes d\u00e9pressifs : essai pilote contr\u00f4l\u00e9 \u00e0 r\u00e9partition al\u00e9atoire et \u00e0 groupes parall\u00e8les"],"prefix":"10.1177","volume":"71","author":[{"given":"Shahrokh","family":"Shekarriz","sequence":"first","affiliation":[{"name":"McMaster University"},{"name":"Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-9639","authenticated-orcid":false,"given":"Simone N.","family":"Vigod","sequence":"additional","affiliation":[{"name":"Women's College Research Institute, Women's College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Bianco","sequence":"additional","affiliation":[{"name":"University Health 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