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Prior to the skin pigmentation an increased melanocytic activity with ocular manifestations appears, which beyond a certain point in some patients leads to exhaustion of melanocytic activity and to deposit of melanin in the dermis. The melanin\/chlorpromazine complex is discussed and a hypothetical mechanism of chlorpromazine action is proposed which may lead to the described skin and ocular pathology.<\/jats:p>","DOI":"10.1177\/070674376501000205","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T13:20:06Z","timestamp":1493212806000},"page":"112-124","source":"Crossref","is-referenced-by-count":11,"title":["Skin Pigmentation, A Rare Side Effect of Chlorpromazine"],"prefix":"10.1177","volume":"10","author":[{"given":"T. A.","family":"Ban","sequence":"first","affiliation":[{"name":"Verdun Protestant Hospital, Verdun, Quebec."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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