{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:14:55Z","timestamp":1777518895444,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1973,10,1]],"date-time":"1973-10-01T00:00:00Z","timestamp":118281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Psychiatric Association Journal"],"published-print":{"date-parts":[[1973,10]]},"abstract":"<jats:p>Sixty-five depressed outpatients were treated in an open label cross-over study of chlordiazepoxide and amitriptyline. The treatment was changed only in those patients in whom the response to the first medication was inadequate. Global rating and self-rating scales were compounded into a rating of treatment preference.<\/jats:p>\n                  <jats:p>For the group as a whole chlordiazepoxide appeared to be more effective than amitriptyline. The patients who responded to treatment with chlordiazepoxide tended to show reactivity, symptoms of anxiety or tension and were not retarded.<\/jats:p>\n                  <jats:p>Chlordiazepoxide appeared to be more effective in patients who were initially diagnosed as suffering from exogenous depressions, whereas amitriptyline appeared to be more effective in those with endogenous depressions.<\/jats:p>\n                  <jats:p>The findings suggest that in a large proportion of depressed patients it is possible to predict from their clinical features which class of psychotropic drugs is likely to be more effective.<\/jats:p>","DOI":"10.1177\/070674377301800508","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T13:09:24Z","timestamp":1493212164000},"page":"393-398","source":"Crossref","is-referenced-by-count":3,"title":["Chlordiazepoxide in Depressive Neurosis: An Open Label Cross-over Study with Amitriptyline"],"prefix":"10.1177","volume":"18","author":[{"given":"Robert","family":"Kellner","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"bibr1-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.120.5.429"},{"key":"bibr2-070674377301800508","first-page":"1","volume":"4","author":"Freeman H.","year":"1967","journal-title":"Psychopharmacol. Bull."},{"key":"bibr3-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(196010)16:4<399::AID-JCLP2270160416>3.0.CO;2-E"},{"key":"bibr4-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(65)72257-3"},{"key":"bibr5-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-197008000-00002"},{"key":"bibr6-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700044809"},{"key":"bibr7-070674377301800508","first-page":"459","volume":"11","author":"Kellner R.","year":"1969","journal-title":"Br. J. Clin. Pract."},{"key":"bibr8-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700046377"},{"key":"bibr9-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.118.543.195"},{"key":"bibr10-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.507.193"},{"key":"bibr11-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(72)71383-3"},{"key":"bibr12-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070080011002"},{"key":"bibr13-070674377301800508","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03130090039009"},{"key":"bibr14-070674377301800508","first-page":"30","volume":"31","author":"Rickels K.","year":"1970","journal-title":"Dis. Nerv. Syst."}],"container-title":["Canadian Psychiatric Association Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674377301800508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674377301800508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:06:41Z","timestamp":1777392401000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/070674377301800508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1973,10]]}},"alternative-id":["10.1177\/070674377301800508"],"URL":"https:\/\/doi.org\/10.1177\/070674377301800508","relation":{},"ISSN":["0008-4824"],"issn-type":[{"value":"0008-4824","type":"print"}],"subject":[],"published":{"date-parts":[[1973,10]]}}}