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The study incorporated two conditions thought to be essential for an adequate evaluation of the treatment: a placebo-ECT group; and double-blind procedures. The failure of the study revealed the difficulty of conducting to completion an adequately controlled investigation of a treatment already accepted by clinicians. Other placebo-controlled double-blind studies are reviewed, and alternative study designs are discussed.<\/jats:p>","DOI":"10.1177\/070674377602100202","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T13:05:20Z","timestamp":1493211920000},"page":"61-67","source":"Crossref","is-referenced-by-count":3,"title":["Electroconvulsive Therapy: Is Further Investigation Necessary?"],"prefix":"10.1177","volume":"21","author":[{"given":"C. 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