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Consideration of the neuropathological changes suggest that this disease may involve the interaction of at least three processes: a viral-like infection, a disorder in the immune system and the neurotoxic effect of an environmental agent. The evidence in support of this hypothesis is reviewed.<\/jats:p>","DOI":"10.1177\/070674377802300406","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T13:01:15Z","timestamp":1493211675000},"page":"229-233","source":"Crossref","is-referenced-by-count":27,"title":["Brain Aging and Alzheimer's Disease\n                    <sup>*<\/sup>"],"prefix":"10.1177","volume":"23","author":[{"given":"D.R.","family":"Crapper","sequence":"first","affiliation":[{"name":"Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Deboni","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"bibr1-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197601222940402"},{"key":"bibr2-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1970.tb02831.x"},{"key":"bibr3-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1975.tb00388.x"},{"key":"bibr4-070674377802300406","volume-title":"The Neurobiology of Aging, Vol. IV.","author":"Crapper D.R."},{"key":"bibr5-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1038\/271566a0"},{"key":"bibr6-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1126\/science.142303"},{"key":"bibr7-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.16.4.213"},{"key":"bibr8-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690693"},{"key":"bibr9-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1007\/BF01812689"},{"key":"bibr10-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3093-6_13"},{"key":"bibr11-070674377802300406","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685368"},{"key":"bibr12-070674377802300406","first-page":"1222","volume":"8","author":"Kalter S.","year":"1975","journal-title":"NY State J. 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