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This was done by observing the sero-response of seronegative children to rubella vaccine, since 90% of patients with known CR who are seronegative fail to seroconvert to the vaccine. Of the 225 seronegative children 23 did not seroconvert after a single vaccination. Five of these failed to respond on revaccination. These five children had a high frequency of severe language and learning disability as well as frequent diagnoses of major CNS disorders. It is likely that a far greater number of children in the population studied had CR, since our methods identify only about 20% of those affected. Clinically, a specific diagnosis of CR is helpful in facilitating genetic counselling and in allowing the clinician to offer a more hopeful prognosis.<\/jats:p>","DOI":"10.1177\/070674378302800110","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T04:43:49Z","timestamp":1493181829000},"page":"45-48","source":"Crossref","is-referenced-by-count":2,"title":["A Search for Congenital Rubella in Psychiatric Day Treatment, Language and Learning Centres"],"prefix":"10.1177","volume":"28","author":[{"given":"Ronald B.","family":"Feldman","sequence":"first","affiliation":[{"name":"Section of Family Therapy, Department of Psychiatry, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Mendelson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sir Mortimer B. 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Davis-Jewish General Hospital, McGill University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Center for Epidemiologic Studies, National Institute of Mental Health, Rockville, Maryland. At the time of the study, Staff Investigator, Institute of Community and Family Psychiatry, Sir Mortimer B. 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