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A number of aspects of this case are outlined including the difficulties of diagnostic accuracy in major disorders of childhood and adolescence, the existence of biological markers, the implication of environmental stressors and cultural-familial factors. An unusual situation of reversal of index case identification is noted.<\/jats:p>","DOI":"10.1177\/070674378503000711","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T04:37:06Z","timestamp":1493181426000},"page":"530-534","source":"Crossref","is-referenced-by-count":1,"title":["Affective Disorder in an Adolescent"],"prefix":"10.1177","volume":"30","author":[{"given":"Sandra","family":"Fisman","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Western Ontario, London, Ontario"},{"name":"Children's Hospital of Western Ontario, London, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Max","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Western Ontario, London, Ontario"},{"name":"Victoria Hospital, London, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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