{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:28:20Z","timestamp":1777519700896,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>This study investigated the effects of trihexyphenidyl on chlorpromazine (CPZ) plasma levels and clinical state in 20 relatively young schizophrenic patients diagnosed using the DSM-III. Spontaneous changes in CPZ plasma levels over time were also examined.<\/jats:p>\n                  <jats:p>Trihexyphenidyl significantly increased CPZ plasma levels (average 41 %) but did not produce clinical change. The trihexyphenidyl-induced increase in CPZ plasma levels was independent of CPZ oral dosage and of CPZ plasma levels. Chlorpromazine plasma levels decreased non significantly (about 13%) over the four weeks following steady state, but there was marked inter-subject variability, and CPZ levels rose in some subjects. Although identical CPZ doses produced widely variable plasma levels, CPZ plasma levels correlated significantly with oral dose.<\/jats:p>\n                  <jats:p>The views that antiparkinsonian drugs interfere with neuroleptic efficacy, and do so by lowering neuroleptic plasma levels, are questioned.<\/jats:p>","DOI":"10.1177\/070674379003500708","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T04:13:45Z","timestamp":1493180025000},"page":"604-607","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Trihexyphenidyl on Plasma Chlorpromazine in Young Schizophrenics\n                    <sup>*<\/sup>"],"prefix":"10.1177","volume":"35","author":[{"given":"Lawrence","family":"Rockland","sequence":"first","affiliation":[{"name":"Adult Outpatient Department, New York Hospital-Westchester Division, Cornell University Medical College, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cooper","sequence":"additional","affiliation":[{"name":"Analytical Psychopharmacology Laboratories, Nathan Kline Institute, Orangeburg, New York, New York State Psychiatric Institute, New York, New York, Department of Psychiatry, College of Physicians and Surgeons."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Chief of Psychological Services, Extended Treatment Division, New York Hospital-Westchester Division, Cornell University Medical College, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Weber","sequence":"additional","affiliation":[{"name":"Kirby Forensic Psychiatric Center, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Sullivan","sequence":"additional","affiliation":[{"name":"New York Hospital-Westchester Division, Cornell University Medical College, New York, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,10,1]]},"reference":[{"key":"bibr1-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-197307000-00007"},{"key":"bibr2-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1973146978"},{"key":"bibr3-070674379003500708","first-page":"325","volume":"1","author":"Chouinard G.","year":"1977","journal-title":"Commun Psychopharm"},{"key":"bibr4-070674379003500708","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00427479","volume":"49","author":"Kolakowska T.","year":"1976","journal-title":"Psychopharmacol"},{"key":"bibr5-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1980.01780150095010"},{"key":"bibr6-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.130.1.82"},{"key":"bibr7-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770280093010"},{"key":"bibr8-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972136931"},{"key":"bibr9-070674379003500708","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"bibr10-070674379003500708","volume-title":"Global Assessment Scale, third edition.","author":"Endicott J.","year":"1977"},{"key":"bibr11-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760130049008"},{"key":"bibr12-070674379003500708","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/17.8.830"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674379003500708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674379003500708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:09:23Z","timestamp":1777392563000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/070674379003500708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1177\/070674379003500708"],"URL":"https:\/\/doi.org\/10.1177\/070674379003500708","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}