{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:41:32Z","timestamp":1777520492343,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>\n                    Elevated concentrations of blood serotonin have been documented in autistic children and mentally retarded adults. Antiserotonergic pharmacotherapy has been partially effective in treating a subgroup of children with autistic disorder. Therefore, the possibility is raised that an antiserotonergic treatment may be of value to adult psychiatric patients with a history of pervasive developmental disorder. Two such cases are described where the patients underwent psychiatric and neuropsychological examination before and after treatment with risperidone, a potent 5-HT\n                    <jats:sub>2<\/jats:sub>\n                    antagonist with additional D\n                    <jats:sub>2<\/jats:sub>\n                    antagonistic properties. Particular improvements were documented in both patients, despite long histories of cognitive compromise and high likelihood of damage to the central nervous system.\n                  <\/jats:p>","DOI":"10.1177\/070674379403900703","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T03:58:52Z","timestamp":1493179132000},"page":"400-405","source":"Crossref","is-referenced-by-count":63,"title":["Risperidone in the Treatment of Pervasive Developmental Disorder"],"prefix":"10.1177","volume":"39","author":[{"given":"Scot E.","family":"Purdon","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Alberta, Edmonton, Alberta."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Lit","sequence":"additional","affiliation":[{"name":"Homewood Health Centre, Guelph, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Labelle","sequence":"additional","affiliation":[{"name":"Schizophrenia Branch, Institute of Mental Health Research, Royal Ottawa Hospital\/University of Ottawa, Ottawa, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry D.W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Schizophrenia Branch, Institute of Mental Health Research, Royal Ottawa Hospital\/University of Ottawa, Ottawa, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"bibr1-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0787-7_32"},{"key":"bibr2-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199105000-00004"},{"key":"bibr3-070674379403900703","volume-title":"Diagnostic and statistical manual of mental disorders (third edition revised).","year":"1987"},{"key":"bibr4-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198709000-00015"},{"key":"bibr5-070674379403900703","volume-title":"Handbook of autism and pervasive developmental disorders.","author":"Mesaros R.A.","year":"1987"},{"key":"bibr6-070674379403900703","volume-title":"Handbook of autism and pervasive developmental disorders.","author":"Marcus L.M.","year":"1987"},{"key":"bibr7-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00014"},{"key":"bibr8-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01837709"},{"key":"bibr9-070674379403900703","first-page":"136","volume":"35","author":"Asperger H.","year":"1968","journal-title":"Acta Paedopsychiatr"},{"key":"bibr10-070674379403900703","first-page":"45","volume":"13","author":"Asperger H.","year":"1979","journal-title":"Communication"},{"key":"bibr11-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-0025.1951.tb00012.x"},{"key":"bibr12-070674379403900703","first-page":"650","volume":"3","author":"Reiser D.E.","year":"1964","journal-title":"J Am Acad Child Psychiatry"},{"key":"bibr13-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700039623"},{"key":"bibr14-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700053332"},{"key":"bibr15-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790130023003"},{"key":"bibr16-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408557"},{"key":"bibr17-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531783"},{"key":"bibr18-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531717"},{"key":"bibr19-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000018213"},{"key":"bibr20-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207153070307"},{"key":"bibr21-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537957"},{"key":"bibr22-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(61)80261-8"},{"key":"bibr23-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1970.01750060086009"},{"key":"bibr24-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540533"},{"key":"bibr25-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537926"},{"key":"bibr26-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1159\/000468197"},{"key":"bibr27-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537909"},{"key":"bibr28-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1977.01770170031002"},{"key":"bibr29-070674379403900703","first-page":"79","volume":"26","author":"Hoshino Y.","year":"1979","journal-title":"Fukushima J Med Sci"},{"key":"bibr30-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1159\/000118045"},{"key":"bibr31-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1987.tb00677.x"},{"key":"bibr32-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF02206997"},{"key":"bibr33-070674379403900703","first-page":"831","volume":"7","author":"Sloman L.","year":"1991","journal-title":"Pediatr Clin North Am"},{"key":"bibr34-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-7138(09)60241-7"},{"key":"bibr35-070674379403900703","first-page":"148","volume":"22","author":"Schuster C.R.","year":"1986","journal-title":"Psychopharmacol Bull"},{"key":"bibr36-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1978.tb31530.x"},{"key":"bibr37-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1992-2_20"},{"key":"bibr38-070674379403900703","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-3565(25)24408-1","volume":"244","author":"Janssen P.A.J.","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr39-070674379403900703","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0022-3565(25)13416-2","volume":"247","author":"Leysen J.E.","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr40-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199302000-00004"},{"key":"bibr41-070674379403900703","first-page":"233","volume":"88","author":"Roose K.","year":"1988","journal-title":"Acta Psychiatr Belg"},{"key":"bibr42-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1007\/BF00589890"},{"key":"bibr43-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(89)90034-0"},{"key":"bibr44-070674379403900703","first-page":"876","volume":"46","author":"Meco G.","year":"1989","journal-title":"Curr Ther Res"},{"key":"bibr45-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470050307"},{"key":"bibr46-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000295950"},{"key":"bibr47-070674379403900703","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014509"},{"key":"bibr48-070674379403900703","volume-title":"Wechsler Adult Intelligence Scale: revised manual.","author":"Wechsler D.","year":"1981"},{"key":"bibr49-070674379403900703","volume-title":"Peabody Picture Vocabulary Test: revised manual.","author":"Dunn L.M.","year":"1981"},{"key":"bibr50-070674379403900703","volume-title":"DRS: Dimentia Rating Scale professional manual.","author":"Mattis S.","year":"1988"},{"key":"bibr51-070674379403900703","volume-title":"The Boston Naming Test.","author":"Kaplan E.F.","year":"1978"},{"key":"bibr52-070674379403900703","volume-title":"The Halstead-Reitan neuropsychological battery: theory and clinical interpretation.","author":"Reitan R.M.","year":"1985"},{"key":"bibr53-070674379403900703","volume-title":"A manual for the Wisconsin Card Sorting Test.","author":"Heaton R.K.","year":"1981"},{"key":"bibr54-070674379403900703","author":"Benton A.L.","year":"1983","journal-title":"Iowa,"},{"key":"bibr55-070674379403900703","volume-title":"The Wechsler Memory Scale.","author":"Wechsler D.","year":"1985"}],"container-title":["The Canadian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674379403900703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/070674379403900703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:11:44Z","timestamp":1777392704000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/070674379403900703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1177\/070674379403900703"],"URL":"https:\/\/doi.org\/10.1177\/070674379403900703","relation":{},"ISSN":["0706-7437","1497-0015"],"issn-type":[{"value":"0706-7437","type":"print"},{"value":"1497-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}