{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:56:42Z","timestamp":1790938602611,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Explaining the diversity of symptoms that occur in schizophrenia is a major conceptual challenge. Perhaps the most powerful strategy is to identify a fundamental cognitive process and\/or a fundamental neural circuit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Convergent data from our research group in Iowa and from investigators in other centres are summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The thalamus plays a key role in information processing. A defect in circuitry connecting the thalamus, frontal cortex, and cerebellum could explain a wide range of symptoms. Neuropathology and imaging studies suggest that patients with schizophrenia may have abnormalities in this circuitry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The fundamental deficit in schizophrenia may be conceptualized as a \u201ccognitive dysmetria\u201d characterized by impairments in coordinating the perception, encoding, retrieval, and prioritization of experience and information.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674379704200104","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T21:49:13Z","timestamp":1483652953000},"page":"27-33","source":"Crossref","is-referenced-by-count":182,"title":["The Role of the Thalamus in Schizophrenia"],"prefix":"10.1177","volume":"42","author":[{"given":"Nancy C","family":"Andreasen","sequence":"first","affiliation":[{"name":"Andrew H Woods Professor of Psychiatry, Mental Health Clinical Research Center, The University of Iowa College of Medicine and University of Iowa Hospitals and Clinics, Iowa City, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,2,1]]},"reference":[{"key":"bibr1-070674379704200104","volume-title":"Dementia praecox and paraphrenia","author":"Kraepelin E","year":"1919"},{"key":"bibr2-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.106.442.246"},{"key":"bibr3-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90890-4"},{"key":"bibr4-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230024005"},{"key":"bibr5-070674379704200104","volume-title":"Can schizophrenia be localized in the brain?","author":"Andreasen NC","year":"1986"},{"key":"bibr6-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90221-9"},{"key":"bibr7-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820120031006"},{"key":"bibr8-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.11.1457"},{"key":"bibr9-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.5.704"},{"key":"bibr10-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1038\/378176a0"},{"key":"bibr11-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820150036003"},{"key":"bibr12-070674379704200104","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208273270905"},{"key":"bibr13-070674379704200104","volume-title":"Dementia praecox of the group of schizophrenias","author":"Bleuler E.","year":"1911"},{"key":"bibr14-070674379704200104","volume-title":"Parallel distributed processing: Exploring in the microstructure of cognition. 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