{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:50:38Z","timestamp":1777521038379,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Psychiatry"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The presence of a 47,XYY karyotype in boys with pervasive developmental disorders (PDDs) has rarely been described in the past. Herein, 2 boys with PDDs and a supernumerary Y chromosome are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The case histories of the 2 patients are described along with the results of associated testing. The literature on psychosocial development as well as brain morphology and physiology in males with 47,XYY karyotypes is reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both boys had presentations typical of PDDs, one with autistic disorder and the other with PDD not otherwise specified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The finding that, in a clinic for children with developmental disorders, 2 of 40 male referrals had 47,XYY karyotypes suggests that the rate of this sex chromosome anomaly may be increased in PDDs. An extra Y chromosome may be related to abnormal brain development, which may, in turn, predispose vulnerable males to PDDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/070674379804300611","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:36:50Z","timestamp":1483648610000},"page":"619-622","source":"Crossref","is-referenced-by-count":35,"title":["47,XYY Karyotypes and Pervasive Developmental Disorders"],"prefix":"10.1177","volume":"43","author":[{"given":"Rob","family":"Nicolson","sequence":"first","affiliation":[{"name":"Resident, Department of Psychiatry, University of Toronto, Toronto, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shree","family":"Bhalerao","sequence":"additional","affiliation":[{"name":"Resident, Department of Psychiatry, University of Toronto, Toronto, 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