{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:41:27Z","timestamp":1777783287679,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Appl Gerontol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>The goals of this study were to identify patterns of polysubstance use and their associations with stressful life events among U.S. late middle-aged and older adults and examine whether gender moderates these associations. Adults aged 50 and older (N = 14,738) from the National Epidemiological Survey on Alcohol and Related Conditions-III were included. Latent class analysis was conducted to identify patterns of polysubstance use. Weighted multinomial logistic regression was estimated with a generalized structural equation model. Three different polysubstance use patterns (non-users\/low substance users; cannabis and excessive alcohol users; painkiller and sedative\/tranquilizer misusers) were identified. Higher levels of stressful life events were associated with patterns of polysubstance use. Gender moderated the association between stressful life events and co-misusing painkillers and sedatives\/tranquilizers ( p &lt; 0.05). Substance use prevention efforts should consider aging adults\u2019 patterns of polysubstance use and associated stressful life events when designing and implementing gender-specific polysubstance use prevention interventions.<\/jats:p>","DOI":"10.1177\/07334648231165256","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T08:13:32Z","timestamp":1680077612000},"page":"1867-1876","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Stressful Life Events and Patterns of Polysubstance Use Among U.S. Late Middle-Aged and Older Adults: A Latent Class Analysis"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-9681","authenticated-orcid":false,"given":"Tzung-Shiang","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesa","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan T.","family":"Macy","sequence":"additional","affiliation":[{"name":"Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany C.","family":"Bray","sequence":"additional","affiliation":[{"name":"Institute for Health Research and Policy, The University of Illinois at Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-2172","authenticated-orcid":false,"given":"Hsien-Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"bibr1-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1177\/0022427801038004001"},{"key":"bibr2-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1177\/002204261004000204"},{"key":"bibr3-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-3289(96)90227-8"},{"key":"bibr4-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1093\/acrefore\/9780190264079.013.249"},{"key":"bibr5-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1177\/1049909117743956"},{"key":"bibr6-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2019.08.001"},{"key":"bibr7-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00949-3"},{"key":"bibr8-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(01)00192-1"},{"key":"bibr9-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0662-2"},{"key":"bibr10-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"key":"bibr11-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2021.1891603"},{"key":"bibr12-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000625"},{"key":"bibr13-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/50B.4.S205"},{"key":"bibr14-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.11.026"},{"key":"bibr15-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.7517"},{"key":"bibr16-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.238287"},{"key":"bibr17-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12424"},{"key":"bibr18-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.07.004"},{"key":"bibr19-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2010.00080.x"},{"key":"bibr20-07334648231165256","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6817a3"},{"key":"bibr21-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106528"},{"key":"bibr22-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-011-0201-1"},{"key":"bibr23-07334648231165256","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-018-1550-x"},{"key":"bibr51-07334648231165256","unstructured":"Lipari R. 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