{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:05:46Z","timestamp":1782536746580,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA039928"],"award-info":[{"award-number":["R01 DA039928"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","award":["Addictions Grand Challenge Initiative"],"award-info":[{"award-number":["Addictions Grand Challenge Initiative"]}],"id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Appl Gerontol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>The goal of this study is to investigate the association between chronic non-cancer pain (CNCP) and mild cognitive impairment (MCI)\/Alzheimer\u2019s disease and related dementias (ADRDs) development among adults aged \u226550 using administrative claims data from a national commercial health insurance company during 2007\u20132017. To reduce selection bias, propensity-score matching was applied to select comparable CNCP and non-CNCP patients. Time-dependent Cox proportional-hazards regressions were conducted to estimate the hazard ratios (HRs) of incident MCI\/ADRDs. Of 170,900 patients with\/without CNCP, 0.61% developed MCI and 2.33% had been diagnosed with ADRDs during the follow-up period. Controlling for potential confounders, CNCP patients had a 123% increase in MCI risk (HR = 2.23; 95% CI = 1.92\u20132.58) and a 44% increase in ADRDs risk (HR = 1.44; 95% CI = 1.34\u20131.54) relative to non-CNCP patients. CNCP is a risk factor for MCI\/ADRDs. Promoting awareness and improving early CNCP diagnosis in middle-aged and older adults should be incorporated into cognitive impairment and dementia prevention.<\/jats:p>","DOI":"10.1177\/07334648241237340","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:57:05Z","timestamp":1709809025000},"page":"1438-1448","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic Non-cancer Pain and Associated Risks of Incident Mild Cognitive Impairment and Alzheimer\u2019s Disease and Related Dementias in Middle-Aged and Older Adults"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-6563","authenticated-orcid":false,"given":"Yi-Han","family":"Hu","sequence":"first","affiliation":[{"name":"Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Chul","family":"Seo","sequence":"additional","affiliation":[{"name":"Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesa","family":"Huber","sequence":"additional","affiliation":[{"name":"Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Shih","sequence":"additional","affiliation":[{"name":"Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-2172","authenticated-orcid":false,"given":"Hsien-Chang","family":"Lin","sequence":"additional","affiliation":[{"name":"Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"bibr1-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12741"},{"key":"bibr2-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"bibr3-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1151"},{"key":"bibr4-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02767.x"},{"key":"bibr5-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.06.013"},{"key":"bibr6-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00412.x"},{"key":"bibr8-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1608-z"},{"key":"bibr9-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02758.x"},{"key":"bibr10-07334648241237340","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"bibr11-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2022.0346"},{"key":"bibr13-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13562"},{"key":"bibr14-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.125.3.356"},{"key":"bibr15-07334648241237340","doi-asserted-by":"publisher","DOI":"10.2174\/1567205016666181212162424"},{"key":"bibr16-07334648241237340","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191311"},{"key":"bibr17-07334648241237340","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200960"},{"key":"bibr18-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001673"},{"key":"bibr19-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00212.x"},{"key":"bibr20-07334648241237340","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17155454"},{"key":"bibr21-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2022.4732"},{"key":"bibr22-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.01.013"},{"key":"bibr23-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1003"},{"key":"bibr24-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.08.006"},{"key":"bibr25-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01326.x"},{"key":"bibr26-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.10.022"},{"key":"bibr27-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.07.029"},{"key":"bibr28-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-71694-7_1"},{"key":"bibr29-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/70.1.41"},{"issue":"4","key":"bibr30-07334648241237340","first-page":"e7855","volume":"12","author":"Sangha P. S.","year":"2020","journal-title":"Cureus"},{"key":"bibr31-07334648241237340","volume-title":"SAS\/STAT\u00ae 14.2 user\u2019s guide","author":"SAS Institute Inc","year":"2016"},{"key":"bibr32-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1062"},{"key":"bibr33-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"bibr34-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.09.002"},{"key":"bibr35-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.06.009"},{"key":"bibr36-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv166"},{"key":"bibr37-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1177\/2049463713493264"},{"key":"bibr38-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.07.001"},{"key":"bibr39-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1159\/000354370"},{"key":"bibr40-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00091.x"},{"key":"bibr41-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.1622"},{"key":"bibr42-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47005-x"},{"issue":"2","key":"bibr43-07334648241237340","first-page":"436","volume":"75","author":"Zimmer Z.","year":"2020","journal-title":"Journals of Gerontology Series B: Psychological Sciences and Social Sciences"},{"key":"bibr44-07334648241237340","doi-asserted-by":"publisher","DOI":"10.1177\/0898264320931665"}],"container-title":["Journal of Applied Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07334648241237340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/07334648241237340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/07334648241237340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:36:03Z","timestamp":1777491363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/07334648241237340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/07334648241237340"],"URL":"https:\/\/doi.org\/10.1177\/07334648241237340","relation":{},"ISSN":["0733-4648","1552-4523"],"issn-type":[{"value":"0733-4648","type":"print"},{"value":"1552-4523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}