{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:07:23Z","timestamp":1780675643530,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"King Saud University in Saudi Arabia","award":["ORF-2026-1090"],"award-info":[{"award-number":["ORF-2026-1090"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Appl Gerontol"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We investigated the effects of handgrip strength (HGS) on the relationship between depression and 23 types of cancers in a large sample of European adults aged 50 and over (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 93,545) from 28 countries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed cross-sectional data from the Survey of Health, Ageing, and Retirement in Europe (SHARE), collected between 2013 and 2021. We used logistic regression with an interaction term to specifically assess the moderating role of HGS in this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants with depression exhibited a higher risk of cancer than those without depression (8.5% vs. 4.7%, respectively). The risk of cancer was higher among participants with low HGS than those with normal HGS (7.78% vs. 5.48%, respectively). HGS moderated the relationship between depression and cancer (\u03b2 = 0.00277,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), across the range of depression scores (0\u201310 on the Euro-D scale).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher HGS strengthens the association between depression and cancer in old age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07334648261457679","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:47:39Z","timestamp":1780465659000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Handgrip Strength and the Association Between Depression and Cancer in Older Adults"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-7172","authenticated-orcid":false,"given":"Rizwan","family":"Qaisar","sequence":"first","affiliation":[{"name":"University of Sharjah"},{"name":"University of Sharjah"},{"name":"University of Sharjah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Azhar","family":"Hussain","sequence":"additional","affiliation":[{"name":"University of Sharjah"},{"name":"Roskilde University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-0686","authenticated-orcid":false,"given":"Asima","family":"Karim","sequence":"additional","affiliation":[{"name":"University of Sharjah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdos","family":"Ahmad","sequence":"additional","affiliation":[{"name":"University of Sharjah"},{"name":"University of Sharjah"},{"name":"University of Sharjah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Naheed","sequence":"additional","affiliation":[{"name":"Shifa Tameer-e-Millat University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Saeed","sequence":"additional","affiliation":[{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abdel Salam Mohamed","sequence":"additional","affiliation":[{"name":"King Saud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1443-6249","authenticated-orcid":false,"given":"Shaea A.","family":"Alkahtani","sequence":"additional","affiliation":[{"name":"King Saud University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6083"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt088"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.05.001"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30019-2"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003138"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.36416\/1806-3756\/e20220465"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.07.040"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2024.102988"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2017.04.026"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1491584"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18189684"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00783-9"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa100"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_77_21"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e81"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12863"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt433"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-024-02800-z"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04233-1"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-023-03547-2"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.07.004"},{"key":"e_1_3_6_24_1","article-title":"Survey of health, ageing and retirement in Europe (SHARE) wave 8. 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