{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T13:39:42Z","timestamp":1792935582380,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["24010901164"],"award-info":[{"award-number":["24010901164"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Appl Gerontol"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether chair-rise difficulty functions as a functional mediator in the association between loneliness\/social isolation and incident osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 6,232 adults \u226550 in 12 European countries (SHARE waves 7\u20139, 2017\u20132022). Social isolation and loneliness were exposures; depression, physical inactivity, and chair-rise difficulty were mediators; OA onset was the outcome. Structural equation modeling tested mediation, adjusting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No direct associations were found; both exposures had significant indirect effects via depression and functional decline. Chair-rise difficulty was the strongest mediator (\u03b2 = 0.74, p &lt; 0.001), followed by depression (\u03b2 = 0.04, p = 0.033). Physical inactivity acted indirectly through chair-rise difficulty (\u03b2 = 0.26, p &lt; 0.001). Female sex and older-age independently increased OA incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Loneliness and social isolation were indirectly linked to incident OA via psychological, behavioral, and functional mechanisms. Chair-rise difficulty is a functional intermediary linking psychosocial distress to physical vulnerability and increased OA incidence, not a direct cause of joint-degeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/07334648261500729","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:10:02Z","timestamp":1792685402000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chair-Rise Difficulty as a Functional Correlate in the Longitudinal Association Between Loneliness and Incident Osteoarthritis in Older Adults"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-0686","authenticated-orcid":false,"given":"Asima","family":"Karim","sequence":"first","affiliation":[{"name":"University of Sharjah"},{"name":"University of Sharjah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Azhar Hussain","sequence":"additional","affiliation":[{"name":"University of Sharjah"},{"name":"Roskilde University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-7172","authenticated-orcid":false,"given":"Rizwan","family":"Qaisar","sequence":"additional","affiliation":[{"name":"University of Sharjah"},{"name":"University of Sharjah"},{"name":"University of Sharjah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6045"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt088"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000777"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-19463-0"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2025.117703"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S491979"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics9050119"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2020.11.010"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-026-01523-9"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-024-01420-4"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13202654"},{"key":"e_1_3_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.70093"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.70175"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-025-06082-9"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/08964289.2020.1813682"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-93030-4"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2024.1302574"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.2020-0159"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1172552"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50528-z"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.3928\/19404921-20230503-02"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.174.4.330"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-025-01536-0"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-024-02800-z"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03128-y"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2025.105984"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02172-2"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.09.026"},{"key":"e_1_3_7_32_1","volume-title":"Survey of health, ageing and retirement in Europe (SHARE)","author":"SHARE","unstructured":"SHARE. 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