{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:42Z","timestamp":1777922922239,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>\n                    Objective: To study the effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury. Methods: The rats in groups 1, 2 and 3 were sc injected with 0.75, 1.5 and 2.5mg\/kg HgCl\n                    <jats:sub>2<\/jats:sub>\n                    , respectively. Fourth group rats were ip injected with 0.5mmol\/kg BSO and 4h later sc administrated with 0.75mg\/kg HgCl\n                    <jats:sub>2<\/jats:sub>\n                    . The rats in groups 5, 6 and 7 were ip injected with 3 mmol\/kg GSH, 4mmol\/kg Vit-C, 200 \u03bcmol\/kg DMPS, respectively, and 2h later sc administrated with 2.5mg\/kg HgCl\n                    <jats:sub>2<\/jats:sub>\n                    . Eighth group rats were sc injected with saline as a control. Mercury concentrations in the liver, renal cortex and urine, urinary NAG, ALP, LDH activities, protein and BUN contents were determined. Results: Urinary NAG, ALP activities, protein and BUN contents in the rats of BSO pretreatment group were significantly higher than that of 0.75 mg\/kg HgCl\n                    <jats:sub>2<\/jats:sub>\n                    alone group and control group. As compared with 2.5 mg\/kg HgCl\n                    <jats:sub>2<\/jats:sub>\n                    alone group, urinary NAG, ALP, LDH activities, urinary protein and BUN contents decreased significantly. Conclusion: BSO pretreatment could enhance the renal toxicity of mercury and GSH, Vit-C and DMPS pretreatment had antagonistic effects on nephrotoxicity of mercury. Toxicology and Industrial 2007; 23: 403\u2014410.\n                  <\/jats:p>","DOI":"10.1177\/0748233707077431","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T08:14:05Z","timestamp":1205309645000},"page":"403-410","source":"Crossref","is-referenced-by-count":8,"title":["Effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury"],"prefix":"10.1177","volume":"23","author":[{"family":"Zhaofa Xu","sequence":"first","affiliation":[{"name":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jinghua Yang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jiaming Yu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zhongwei Yin","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Wei Sun","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jing Li","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of 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