{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:45Z","timestamp":1777922925214,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>The human teratogenic potential of chlordiazepoxide is debated. To study the effects on the fetal development of very large doses of chlordiazepoxide that were used for a suicide attempt during pregnancy, self-poisoned pregnant women were identified from patients in a toxicological inpatient clinic in Budapest, Hungary. Comparisons were made between congenital abnormalities, intrauterine fetal development, and cognitive\u2013behavioral status of the exposed children born to mothers who attempted suicide with chlordiazepoxide alone or in combination with other drugs during pregnancy and their sib controls. Of 1044 women with self-poisoning during pregnancy between 1960 and 1993, 88 (8.4%) used chlordiazepoxide with or without other drugs for suicide attempt; 35 of these women delivered live-born infants. Doses of chlordiazepoxide taken ranged between 20 and 300\u00a0mg, with a mean of 117\u00a0\u00b1\u00a086\u00a0mg. Of 35 exposed children, six (17.1 %) were affected with congenital abnormalities compared with three (13.6%) of their 22 sibs (OR with 95% CI: 1.3 (0.3\u20134.4). Of 18 pregnant women who attempted suicide between the 4th and 12th postconceptional week, the period most sensitive to congenital malformation, four delivered live-born children affected with a congenital abnormality (atrial septal defect type II, complex defect of respiratory system, mild pyelectasis because of the stenosis of ureteropelvic junction, congenital inguinal hernia). Two other children had fetal alcohol syndrome and unrecognized multiple congenital abnormality including talipes equinovarus, deformation type, and four minor anomalies. The pregnancy age\u2013specific mean birth weight indicated intrauterine fetal growth retardation, which was confirmed by a dose\u2013response relationship and by the higher rate of low birth\u2013weight newborns. Cognitive status and behavioral scale of exposed children did not indicate neurotoxic effects. Very large doses of chlordiazepoxide used for suicide attempts during pregnancy did not induce a higher rate of congenital abnormalities but were associated with dose-dependent intrauterine growth retardation.<\/jats:p>","DOI":"10.1177\/0748233708089018","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T12:10:58Z","timestamp":1221567058000},"page":"41-51","source":"Crossref","is-referenced-by-count":14,"title":["A study of the teratogenic and fetotoxic effects of large doses of chlordiazepoxide used for self-poisoning by 35 pregnant women"],"prefix":"10.1177","volume":"24","author":[{"given":"J","family":"Gidai","sequence":"first","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary; Second Department of Obstetrics and Gynaecology, School of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynaecology, School of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"B\u00e1nhidy","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynaecology, School of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AE","family":"Czeizel","sequence":"additional","affiliation":[{"name":"Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"atypb1","first-page":"336","volume":"58","author":"Bracken MB","year":"1981","journal-title":"Obstet Gynecol"},{"key":"atypb2","volume-title":"Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk","author":"Briggs GG","year":"2005"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(80)90012-8"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197507242930415"},{"key":"atypb5","first-page":"237","volume-title":"Genetic Toxicology of Environmental Chemicals. Part B: Genetic Effects and Applied Mutagenesis.","author":"Czeizel AE","year":"1986"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/0748233708089020"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90548-6"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(1997)30:2<240::AID-EM17>3.0.CO;2-D"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2004.03.009"},{"key":"atypb10","first-page":"179","volume":"12","author":"Czeizel AE","year":"2004","journal-title":"Cent Eur J Public Health"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1032"},{"key":"atypb12","first-page":"209","volume":"25","author":"Czeizel AE","year":"1984","journal-title":"Acta Paediatr Hung"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316249"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00216-0"},{"key":"atypb15","first-page":"37434","volume":"44","author":"FDA","year":"1980","journal-title":"Fed Regist"},{"key":"atypb16","volume-title":"The Effects of Drugs on the Fetus and Nursing Infant.","author":"Friedman JM","year":"1996"},{"key":"atypb17","first-page":"83","volume":"3","author":"Guram MS","year":"1982","journal-title":"Neurotoxicology"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197504032921405"},{"key":"atypb19","volume-title":"Birth Defects and Drugs in Pregnancy.","author":"Heinonen OP","year":"1977"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.3109\/00016348809029859"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198223050-00002"},{"key":"atypb22","first-page":"375","volume":"5","author":"Kanto J","year":"1973","journal-title":"Ann Clin Res"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.3109\/00016347609156779"},{"key":"atypb24","first-page":"347","volume":"32","author":"Lendvay A","year":"1992","journal-title":"Acta Paediatr Hung"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197412122912402"},{"key":"atypb26","volume-title":"Drugs in Pregnancy and Lactation","author":"Rosa F","year":"1993"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112701"},{"key":"atypb28","first-page":"437","volume":"46","author":"Saito H","year":"1984","journal-title":"Res Commun Clin Pathol Pharmacol"},{"key":"atypb29","volume-title":"Catalog of Teratogenic Agents","author":"Shepard TH","year":"2004"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5921.729-b"},{"key":"atypb31","first-page":"148","volume":"2","author":"Szegal B","year":"1980","journal-title":"Hung Psychol"},{"key":"atypb32","volume-title":"Pharmacology of Benzodiazepines.","author":"Usdin E","year":"1982"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113749"},{"key":"atypb34","first-page":"1293","volume":"45","author":"Wyss S","year":"1960","journal-title":"Schweiz Med Wochenschr"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708089018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708089018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:33:58Z","timestamp":1777667638000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233708089018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":34,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1177\/0748233708089018"],"URL":"https:\/\/doi.org\/10.1177\/0748233708089018","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}