{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:56:10Z","timestamp":1790758570094,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>The present study was undertaken to evaluate the effect of fluoride toxicity on the reproductive system of male rats. Sexually mature male Wistar rats were exposed to 2, 4, and 6 ppm sodium fluoride in their drinking water for 6 months ad libitum. Sperm motility and density in cauda epididymis were assessed. Biochemical and histological analysis were performed in reproductive organs. Fluoride treatment brought about a significant decrease in the weight of testis, epididymis, and ventral prostate. The sperm motility and density were significantly reduced. There was a marked reduction in the number of primary spermatocyte, secondary spermatocyte, and spermatids. The Sertoli cell counts and their cross sectional surface areas were significantly decreased. The Leydig cell nuclear area and the number of mature Leydig cells were also significantly decreased. The protein content of the testis and epididymis were significantly reduced. Fructose in the seminal vesicles and cholesterol in testes were increased significantly. In conclusion, sodium fluoride administrated in drinking water of 2, 4, and 6 ppm concentration for 6 months to male rats adversely affected their fertility and reproductive system.<\/jats:p>","DOI":"10.1177\/0748233708089041","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T12:08:14Z","timestamp":1213877294000},"page":"507-513","source":"Crossref","is-referenced-by-count":53,"title":["The toxic effects of sodium fluoride on the reproductive system of male rats"],"prefix":"10.1177","volume":"23","author":[{"given":"RS","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Zoology, Center for Advanced Studies, University of                         Rajasthan, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TI","family":"Khan","sequence":"additional","affiliation":[{"name":"Indira Gandhi Center for Human Ecology, Environmental and Population                         Studies, University of Rajasthan, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Indira Gandhi Center for Human Ecology, Environmental and Population                         Studies, University of Rajasthan, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JBS","family":"Kachhawa","sequence":"additional","affiliation":[{"name":"Department of Zoology, Center for Advanced Studies, University of                         Rajasthan, Jaipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"atypb2","first-page":"37","volume":"4","author":"Chinoy NJ","year":"1984","journal-title":"Ind Rev Life Sci"},{"key":"atypb3","first-page":"12","volume":"7","author":"Chinoy NJ","year":"1997","journal-title":"Ind J Environ Toxicol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(94)90022-1"},{"key":"atypb5","first-page":"203","volume":"31","author":"Chinoy NJ","year":"1998","journal-title":"Fluoride"},{"key":"atypb6","first-page":"223","volume":"6","author":"D\u2019Souza UJA","year":"2004","journal-title":"Asian J Androl"},{"key":"atypb7","first-page":"128","volume":"33","author":"Elbetieha A","year":"2000","journal-title":"Fluoride"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1080\/15287399409531866"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(02)00038-2"},{"key":"atypb10","first-page":"292","volume":"251","author":"Godehauw W","year":"1988","journal-title":"J Biol Chem"},{"key":"atypb11","first-page":"251","volume":"3","author":"Gonzales GF","year":"2001","journal-title":"Asian J Androl"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2004.06.014"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0700341"},{"key":"atypb14","unstructured":"Kumar A Susheela AK                 . (1994) Ultrastructural studies of spermiogenesis in rabbits exposed to                 chronic fluoride toxicity. In: Proceedings of the XIX conference of the electron                 microscope society of India. 14\u201316 December 1994, New Delhi: National                 Physical Laboratory, pp. 87."},{"key":"atypb15","first-page":"7","volume":"27","author":"Narayana MV","year":"1994","journal-title":"Fluoride"},{"key":"atypb16","unstructured":"Neelam K Suhasini RV Sudhakar RY                 . (1987) Incidence of prevalence of infertility among married male members of                 endemic fluorosis district of Andhra Pradesh (abstract). In: Proceedings of a                 conference of the International society of fluoride research Nyon, Switzerland. pp.                 30."},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(03)00059-8"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0015-0282(16)38823-9","volume":"23","author":"Prasad MRN","year":"1972","journal-title":"Fertil Steril"},{"key":"atypb19","first-page":"49","volume":"22","author":"Ramezani GH","year":"2004","journal-title":"J Ind Soc Pedod Prev Dent"},{"key":"atypb20","first-page":"35","volume":"4","author":"Ratnasooriya WD","year":"2002","journal-title":"Asian J Androl"},{"key":"atypb21","first-page":"9","volume":"38","author":"Sashi A","year":"1990","journal-title":"Folia Morphol"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.2166\/wh.2004.0003"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.3109\/15563659609013768"},{"key":"atypb24","first-page":"182","volume":"14","author":"Zahvoronkov AA","year":"1981","journal-title":"Fluoride"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708089041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708089041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:34:02Z","timestamp":1777667642000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233708089041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1177\/0748233708089041"],"URL":"https:\/\/doi.org\/10.1177\/0748233708089041","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}