{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:47:11Z","timestamp":1790254031584,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n                    Organic solvents can produce ototoxic effects in both man and experimental animals. The objective of this study was to review the literature on the effects of low-level exposure to ethyl benzene on the auditory system and consider its relevance for the occupational settings. Both human and animal investigations were evaluated only for realistic exposure concentrations based on the permissible exposure limits. In Quebec, the Time-Weighed Average Exposure Value for 8\u00a0h (TWAEV) is 100\u00a0ppm (434\u00a0mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ) and the Short-Term Exposure Value for 15\u00a0min (STEV) is 125\u00a0ppm (543\u00a0mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ). In humans, the upper limit for considering ototoxicity data relevant to the occupational exposure situation was set at STEV. Animal data were evaluated only for exposure concentrations up to 100 times the TWAEV. In workers, there is no evidence of either ethyl benzene-induced hearing losses or ototoxic interaction after combined exposure to ethyl benzene and noise. In rats, ethyl benzene affects the auditory function mainly in the cochlear mid-frequency range and ototoxic interaction was observed after combined exposure to noise and ethyl benzene. Further studies with sufficient data on the ethyl benzene exposure of workers are necessary to make a definitive conclusion. Given the current evidence from animal studies, we recommend considering ethyl benzene as an ototoxic agent.\n                  <\/jats:p>","DOI":"10.1177\/0748233708094097","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T10:08:24Z","timestamp":1227175704000},"page":"241-246","source":"Crossref","is-referenced-by-count":10,"title":["Ethyl benzene should be considered ototoxic at occupationally relevant exposure concentrations"],"prefix":"10.1177","volume":"24","author":[{"given":"A","family":"Vyskocil","sequence":"first","affiliation":[{"name":"Groupe de recherche interdisciplinaire en sant\u00e9, D\u00e9partement de sant\u00e9 environnementale et sant\u00e9 au travail, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Leroux","sequence":"additional","affiliation":[{"name":"\u00c9cole d\u2019orthophonie et d\u2019audiologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Truchon","sequence":"additional","affiliation":[{"name":"Institut de recherche Robert-Sauv\u00e9 en sant\u00e9 et en s\u00e9curit\u00e9 du travail, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Lemay","sequence":"additional","affiliation":[{"name":"Institut de recherche Robert-Sauv\u00e9 en sant\u00e9 et en s\u00e9curit\u00e9 du travail, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gendron","sequence":"additional","affiliation":[{"name":"\u00c9cole d\u2019orthophonie et d\u2019audiologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Groupe de recherche interdisciplinaire en sant\u00e9, D\u00e9partement de sant\u00e9 environnementale et sant\u00e9 au travail, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"El Majidi","sequence":"additional","affiliation":[{"name":"Groupe de recherche interdisciplinaire en sant\u00e9, D\u00e9partement de sant\u00e9 environnementale et sant\u00e9 au travail, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Viau","sequence":"additional","affiliation":[{"name":"Groupe de recherche interdisciplinaire en sant\u00e9, D\u00e9partement de sant\u00e9 environnementale et sant\u00e9 au travail, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"atypb1","volume-title":"Toxicological Profile for Ethylbenzene (Draft for Public Comment).","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"2007"},{"key":"atypb2","unstructured":"American Conference of Governmental Industrial Hygienists, (ed) (2007) Documentation of the TLVs and BEIs with Other Worldwide Occupational Exposure Values, CD-ROM, Cincinnati, OH, ACGIH Worldwide."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(96)00214-0"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s101620010050","volume":"1","author":"Cappaert NL","year":"2000","journal-title":"J Assoc Res Otolaryngol"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00141-0"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(02)00208-8"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00373-2"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4878(97)00006-9"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1997.2327"},{"key":"atypb10","first-page":"49","volume":"4","author":"Fechter LD","year":"2002","journal-title":"Noise Health"},{"key":"atypb11","first-page":"437","volume-title":"Scientific Basis of Noise-Induced Hearing Loss.","author":"Franks J","year":"1996"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0636-2"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-006-0124-y"},{"key":"atypb14","unstructured":"Gouvernement du Qu\u00e9bec (2001) Regulation respecting occupational health and safety. Gazette officielle du Qu\u00e9bec Part 2 133: 3888\u20133994."},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)90240-2"},{"key":"atypb16","first-page":"623","volume":"10","author":"Johnson AC","year":"1995","journal-title":"Occup Med"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(97)00049-4"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00174-4"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(99)00030-6"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210600611"},{"key":"atypb21","unstructured":"US National Library of Medicine National Institutes of Health. 1965: 10 june 2007: Toxline [Online] http:\/\/toxnet.nlm.nih.gov\/cgibin\/sis\/htmlgen?TOXLINE (Accessed July 27, 2006)."}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708094097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708094097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:34:10Z","timestamp":1777667650000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233708094097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1177\/0748233708094097"],"URL":"https:\/\/doi.org\/10.1177\/0748233708094097","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}