{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:41:46Z","timestamp":1781908906193,"version":"3.54.5"},"reference-count":58,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>D-Galactosamine (GalN)-induced liver injury is associated with reactive oxygen species and oxidative stress. In the present study, we evaluated the effect of alpha lipoic acid (ALA) supplementation on acute GalN-induced oxidative liver injury. Hepatotoxicity induced by single intraperitoneal injection of GalN (500\u00a0mg\/kg body wt) was evident from increase in lipid peroxidation and serum marker enzymes (asparate transaminase, alanine transaminase, alkaline phosphatase, and lactate dehydrogenase). The decreased activities of enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) as well as glutathione levels were the salient features observed in GalN-induced hepatotoxicity. Pretreatment with ALA (50\u00a0mg\/kg body weight for 7\u00a0days) significantly precluded these changes and prevents the hepatic injury. Hence, this study clearly exemplified that ALA might be a suitable candidate against GalN-induced cellular abnormalities.<\/jats:p>","DOI":"10.1177\/0748233708101215","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T10:28:02Z","timestamp":1231842482000},"page":"635-642","source":"Crossref","is-referenced-by-count":17,"title":["Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury"],"prefix":"10.1177","volume":"24","author":[{"given":"TS","family":"Shanmugarajan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Vel\u2019s College of Pharmacy, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sivaraman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Vel\u2019s College of Pharmacy, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Somasundaram","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Vel\u2019s College of Pharmacy, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Arunsundar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Vel\u2019s College of Pharmacy, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Krishnakumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Vel\u2019s College of Pharmacy, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Balaji","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Dr MGR Educational and Research Institute, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Ravichandiran","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Vel\u2019s College of Pharmacy, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"Aebi H\u2004 (1974) Catalase. In: Bergmeyer, HV, (ed), Methods Enzymatic Analysis, vol. 2. New York, Cheime, Weinheim, FRG: Academic press, pp. 674\u2013684.","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00251-9"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(99)00079-0"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(01)00078-3"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2004.45.5.776"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1191\/0960327103ht358oa"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(88)90018-4"},{"key":"atypb8","first-page":"415","volume":"48","author":"Bose KSC","year":"2007","journal-title":"Singapore Med J"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"atypb10","first-page":"60","volume":"24","author":"Busamante J","year":"1998","journal-title":"Free Rad Biol Med"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00139-8"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","volume":"250","author":"Carlberg I","year":"1975","journal-title":"J Biol Chem"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(99)00090-3"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(73)90017-4"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.3109\/01480547809034433"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0772"},{"key":"atypb18","first-page":"214","volume":"17","author":"Ellman GL","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"atypb19","first-page":"579","volume":"79","author":"El-Mofty SK","year":"1975","journal-title":"Am J Pathol"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1089\/15209150050194279"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0748-5514(85)90011-X"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1723"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520060303"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60097"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(70)90183-2"},{"key":"atypb26","first-page":"401","volume":"107","author":"Hebbel RP","year":"1986","journal-title":"J Lab Clin Med"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0730"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1969.tb00677.x"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(68)90042-7"},{"key":"atypb30","unstructured":"King J\u2004 (1965a) The dehydrogenases or oxidoreductases-lactate dehydrogenase. In: Van, D, (ed), Clinical Enzymology. London: Nostrand Company limited, pp. 83\u201393."},{"key":"atypb31","unstructured":"King J\u2004 (1965b) The dehydrogenases or oxidoreductases-lactate dehydrogenase. In: Van, D, (ed), Clinical Enzymology. London: Nostrand Company limited, pp. 121\u2013138."},{"key":"atypb32","unstructured":"King J\u2004 (1965c) The dehydrogenases or oxidoreductases-lactate dehydrogenase. In: Van, D, (ed), Clinical Enzymology. London, Nostrand Company limited, pp. 191\u2013208."},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.05.018"},{"key":"atypb34","first-page":"72","volume":"68","author":"Korda MM","year":"1996","journal-title":"Ukr Biokhim Zh"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(93)90121-K"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.9.25"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1042\/bj1070637"},{"key":"atypb40","first-page":"277","volume-title":"Advanced in Food and Nutrition Research","author":"Mukherjee PK","year":"2003"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.004"},{"key":"atypb42","first-page":"123","volume":"8","author":"Narasimhanaidu K","year":"2005","journal-title":"Iran J Pharmaco Ther"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.3109\/03602539808996311"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)00017-R"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660170031013"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003258654"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(88)90159-2"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.09.025"},{"key":"atypb49","first-page":"284","volume":"36","author":"Rajesh MG","year":"2004","journal-title":"Indian J Pharmacol"},{"key":"atypb50","first-page":"117","volume":"80","author":"Seckin S","year":"1993","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90281-2"},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1997.sp004024"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-0433-8"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01420-X"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.01.005"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.00040.x"},{"key":"atypb57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0090-9556(25)07199-5","volume":"19","author":"Yuan M","year":"1991","journal-title":"Drug Metab Dispos"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.11.003"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708101215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233708101215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:34:19Z","timestamp":1777667659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233708101215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1177\/0748233708101215"],"URL":"https:\/\/doi.org\/10.1177\/0748233708101215","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}