{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:31Z","timestamp":1777922971568,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n                    Insulin resistance (IR) is recognized as a contributory factor for a variety of liver diseases. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) in a rat model of IR, induced by feeding a high-fructose diet (60 g\/100 g) for 30 days. A sub-lethal dose of CCl\n                    <jats:sub>4<\/jats:sub>\n                    (2 mL\/kg intraperitoneally [i.p.], in corn oil) was administered and the outcome of hepatotoxicity was assessed at 0 hour and at 6, 12, 24 and 36 hours after CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration. After 30 days of fructose feeding, the rats showed IR, decline in liver antioxidant status and rise in lipid peroxidation. Liver dysfunction in fructose-fed rats was evident from a rise in transaminases, total bilirubin and a decrease in albumin\/globulin ratio in plasma and decreases in nitrite, arginase and increase in protein carbonyl and nitrosothiol content in liver. Increased staining for 3-nitro tyrosine (3-NT) antibody was observed in fructose-fed rat liver as compared to control. CCl\n                    <jats:sub>4<\/jats:sub>\n                    (2 mL\/kg) caused 100% mortality in fructose-fed rats within 48 hours, while no death of animals occurred in control. CCl\n                    <jats:sub>4<\/jats:sub>\n                    caused liver damage in both control and fructose-fed rats. Time-based studies showed that progressive liver injury occurred only in fructose-fed rats from 0, 6, 12, 24 hours, with a peak at 36 hours. In control diet\u2014fed rats, the extent of damage was maximum at 24 hours, which declined at 36 hours. Thus, the toxic effects of CCl\n                    <jats:sub>4<\/jats:sub>\n                    are potentiated due to compromised liver function in the setting of IR.\n                  <\/jats:p>","DOI":"10.1177\/0748233709359273","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T23:40:03Z","timestamp":1264549203000},"page":"89-104","source":"Crossref","is-referenced-by-count":11,"title":["Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity"],"prefix":"10.1177","volume":"26","author":[{"given":"M.","family":"Pooranaperundevi","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MS","family":"Sumiyabanu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, 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