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The oxidative modification of the proteins of mitochondrial electron transport chain alters their normal function leading to the state of energy crisis in neurons. Exposure of environmental chemicals such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone in mouse produces the symptoms akin to PD and therefore these neurotoxins are commonly used in experimental studies on PD. Another environmental toxin, paraquat (a commonly used herbicide) has also been implicated with the onset of PD. The neurotoxicity of these chemicals is accompanied by the blockade of electron flow from NADH dehydrogenase to coenzyme Q. The agents with the ability to improve mitochondrial respiration and ATP production have been shown to exert beneficial effects in PD patients as well as in the animal models of PD. This review summarizes the current research implicating the impairment of mitochondrial respiratory chain and the role of environmental toxins in the pathogenesis of PD.<\/jats:p>","DOI":"10.1177\/0748233710362382","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T07:04:03Z","timestamp":1267772643000},"page":"121-128","source":"Crossref","is-referenced-by-count":53,"title":["Environmental toxins and Parkinson\u2019s disease: Putative roles of impaired electron transport chain and oxidative stress"],"prefix":"10.1177","volume":"26","author":[{"given":"Ibrahim","family":"Abdulwahid Arif","sequence":"first","affiliation":[{"name":"Environmental Analysis Unit, Prince Sultan Research Chair for Environment and Wildlife, College of Sciences, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haseeb","family":"Ahmad Khan","sequence":"additional","affiliation":[{"name":"Environmental Analysis Unit, 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