{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:20:57Z","timestamp":1790803257398,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T00:00:00Z","timestamp":1274832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>\n                    Occupational exposure to toxic heavy metals may render industrial workers with thyroid-related problems. Here, we examined the role of ascorbic acid (vitamin C) against hexavalent chromium Cr (VI)-induced damage in rat thyroid gland. Potassium dichromate (K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    ) and ascorbic acid doses were 60 \u00b5g and 120 mg kg\n                    <jats:sup>\u20141<\/jats:sup>\n                    body wt (intraperitoneally [i.p.]) respectively. Treatment regimens were group I rats, saline treated control; group II, only K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    ; group III, ascorbic acid 1 hour prior K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    ; group IV, simultaneous doses of ascorbic acid and K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    , and group V, a combined premix dose of ascorbic acid and K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    (2:1 ratio). Blood samples were taken before dosing the animals and 48 hours post exposure to determine the serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT\n                    <jats:sub>3<\/jats:sub>\n                    ) and free thyroxine (FT\n                    <jats:sub>4<\/jats:sub>\n                    ) concentrations. Toward end of experiment, rats were sacrificed and thyroid glands were processed to evaluate the extent of cellular insult. Results showed significantly increased TSH and decreased FT\n                    <jats:sub>3<\/jats:sub>\n                    and FT\n                    <jats:sub>4<\/jats:sub>\n                    concentrations in groups II, III and IV rats as compared to control levels (p &lt; 0.05). In contrast, in group V rats, serum TSH, FT\n                    <jats:sub>3<\/jats:sub>\n                    and FT\n                    <jats:sub>4<\/jats:sub>\n                    concentrations neared control concentrations. Histopathologically, protective effect of ascorbic acid was found in group V rats only, where thyroid gland structure neared control thyroid except the follicular size that was decreased (p &lt; 0.05). Follicular density was no different from control. Basal laminae were intact, interfollicular spaces were normal. Colloid retraction and\/or reabsorption were reduced maximally. Epithelial cell height was no different from control; epithelial follicular index increased only 1.3 fold, whereas nuclear-cytoplasmic (N\/C) ratio was decreased by 14% only. The study indicates that the ascorbic acid may have the potential to protect thyroid gland from chromium toxicity; however, the study warrants further in-depth experimentation to precisely elucidate this role.\n                  <\/jats:p>","DOI":"10.1177\/0748233710371109","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T20:25:26Z","timestamp":1274905526000},"page":"349-359","source":"Crossref","is-referenced-by-count":22,"title":["Prospective role of ascorbic acid (vitamin C) in attenuating hexavalent chromium-induced functional and cellular damage in rat thyroid"],"prefix":"10.1177","volume":"26","author":[{"family":"Irfan Zia Qureshi","sequence":"first","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,26]]},"reference":[{"issue":"1","key":"atypb1","first-page":"37","volume":"80","author":"Abercrombie M.","year":"1946","journal-title":"Journal of Anatomy"},{"issue":"2","key":"atypb2","first-page":"24","volume":"69","author":"Adamova IaG","year":"2007","journal-title":"Arkhiv Patologii"},{"key":"atypb3","unstructured":"Aftab Z., Ali L., Khan AM, Robinson AC, and Irshad IA ( 2000) Industrial Policy and the Environment in Pakistan . 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