{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:37Z","timestamp":1777922977387,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T00:00:00Z","timestamp":1290729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    Lead (Pb) toxicity is one of the commonest environmental problems in our life; it causes many reversible and irreversible changes in our tissues. This study was carried out to investigate the effect of meso-2,3-dimercaptosuccinic acid (DMSA) on treatment of oxidative stress caused by lead poisoning in rabbits. Lead acetate (Pb(Ac)\n                    <jats:sub>2<\/jats:sub>\n                    ) was orally administrated to rabbits for 21 days and then treated by DMSA for another 21 days. The effect of this treatment was investigated by measuring 2 of the apoptosis proteins p53 and Bcl2. Also, the auto-oxidation rate and their histopathological changes in brain, bone and liver were investigated. Hemoglobin auto-oxidation rate is measured as well as histopathological study of liver. Our data indicate that exposure to rabbits to Pb(Ac)\n                    <jats:sub>2<\/jats:sub>\n                    caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 proteins.\n                  <\/jats:p>","DOI":"10.1177\/0748233710386411","type":"journal-article","created":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T21:04:30Z","timestamp":1290805470000},"page":"271-278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits"],"prefix":"10.1177","volume":"27","author":[{"given":"Ehab","family":"Tousson","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Science, Tanta University, Egypt,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem M","family":"Rafat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, National Research Center, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Hessien","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Tanta University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A","family":"El Barbary","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Tanta University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Sami","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Tanta University, 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