{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:41Z","timestamp":1777922981235,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:00:00Z","timestamp":1300320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    It has been reported that acrylamide can be detected in starchy food treated by high temperature (120\n                    <jats:sup>\u00b0<\/jats:sup>\n                    C). People could be exposed to acrylamide in factory, laboratory, or even in daily life via diet and drinking water. Recently, the toxicity of acrylamide receives more attention. In addition to the neurotoxicity in humans, other toxic effects of acrylamide are worth further investigation. In this study, we investigated whether acrylamide affected the male reproductive system using high-performance liquid chromatography. In this study, the reproductive toxicity of acrylamide was observed in 3-week-old weaning male Sprague-Dawley rats treated with acrylamide at various doses (0, 5, 15 or 30 mg\/kg\/day). The results showed that food availability and reproductive organ indexes of the weaning male rats decreased. Levels of follicle-stimulating hormone and testosterone in serum increased while luteinizing hormone in serum decreased. The histopathological lesions and abnormal sperms presented in weaning rats after acrylamide treatment. The results suggested that there is a toxicological effect of acrylamide on the reproductive system of weaning male rats. Based on the findings above, we suggested that more attention should be paid to the toxicological study of acrylamide on weaning male rats or human beings, rather than just on adult male animals.\n                  <\/jats:p>","DOI":"10.1177\/0748233710394235","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T23:50:17Z","timestamp":1300405817000},"page":"617-627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Toxicological effects of acrylamide on the reproductive system of weaning male rats"],"prefix":"10.1177","volume":"27","author":[{"family":"Yuxin Ma","sequence":"first","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jing Shi","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Meige Zheng","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jing Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Sumin Tian","sequence":"additional","affiliation":[{"name":"Department of Physiology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Xinhong He","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Dexing Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Guoying Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, Basic Medical College, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jiayong Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"atypb1","first-page":"144","volume":"42","author":"Carere A.","year":"2006","journal-title":"Annali Dell\u2019Istituto Superiore di Sanit\u00e0"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.03.003"},{"key":"atypb3","volume-title":"The updated exposure assessment for acrylamide","author":"DiNovi M.","year":"2004"},{"key":"atypb4","volume-title":"Health implications of acrylamide in food","author":"FAO\/WHO","year":"2002"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1021\/jf030204+"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.033308"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(72)90176-7"},{"key":"atypb8","first-page":"37","volume":"158","author":"Ko MH","year":"1999","journal-title":"Neurology"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0537"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1038\/419448a"},{"key":"atypb11","first-page":"874","volume":"266","author":"Murohava T.","year":"1994","journal-title":"American Journal of Physiology"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00204-1"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00290538"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005072-197404000-00006","volume":"33","author":"Schaumburg HH","year":"1974","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"atypb15","unstructured":"Schaumburg HH ( 1980) Experimental and clinical neurotoxicology. London Williams & Wilkins Baltimore , 309-325."},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1038\/419449a"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.117"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.11"},{"key":"atypb19","first-page":"225","volume":"12","author":"Timothyl JS","year":"1991","journal-title":"Neurotoxicology"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(02)00101-6"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(02)00078-3"},{"key":"atypb22","first-page":"492","volume":"13","author":"Wang H.","year":"2007","journal-title":"Zhonghua Nan Ke Xue"},{"key":"atypb23","unstructured":"World Health Organization (1999) WHO Laboratory manual for the examination of human semen and semen cervical mucus interaction. 4th ed. Cambridge : Cambridge University Press, 7-20."},{"key":"atypb24","volume-title":"Study of acrylamide on toxicity of reproductive system in male mice","author":"Xie N.","year":"2007"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-009-0353-5"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2005.6.2.103"},{"key":"atypb27","unstructured":"Zenick H. and Clegg ED ( 1989) Assessment of the male reproductive toxicity: A risk assessment approach. In: Hayes Aw (ed.) Principles and methods of toxicology. 2nd ed. New York: Raven Press, 275."},{"key":"atypb28","unstructured":"Zhang Q. ( 2000) Basis for hygiene toxicology. The people\u2019s medical publishing house: Peking , 249-251."}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233710394235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233710394235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:36:08Z","timestamp":1777667768000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233710394235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,17]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1177\/0748233710394235"],"URL":"https:\/\/doi.org\/10.1177\/0748233710394235","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,17]]}}}