{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:51:01Z","timestamp":1792083061902,"version":"4.4.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T00:00:00Z","timestamp":1304467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    Exposure to hexavalent chromium Cr(VI) compounds is of concern in many Cr-related industries and their surrounding environments. K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    is widely recognized as an animal and human carcinogen, mutagen, and teratogen. The present study investigated the bone maturity of suckling rats whose mothers were treated with K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    . Experiments were carried out on female Wistar rats given 700 ppm of K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    in their drinking water from the 14th day of pregnancy until day 14 after delivery. Exposing dams to K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    caused disorders in the bone of their progeny. As corollary to this, malondialdehyde levels increased, while glutathione, a non-protein thiol and vitamin C decreased. Alteration of the antioxidant system in the treated group was also confirmed by the significant decline of superoxide dismutase, catalase, and glutathione peroxidase activities. Furthermore, K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    induced changes in bone mineralization, especially calcium and phosphorus levels, which decreased. Whereas, in plasma and urine, they increased and decreased inversely. These results suggest that K\n                    <jats:sub>2<\/jats:sub>\n                    Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>7<\/jats:sub>\n                    accelerated bone resorption activity. In fact, in treated pups, total tartrate-resistant acid phosphatase, which reflected bone resorption, was enhanced while total alkaline phosphatase, which reflected bone formation, was reduced. The impairment of bone function was corresponded histologically.\n                  <\/jats:p>","DOI":"10.1177\/0748233710395992","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T23:31:10Z","timestamp":1304551870000},"page":"724-734","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Oxidative stress induced by chromium (VI) in bone of suckling rats"],"prefix":"10.1177","volume":"27","author":[{"given":"Nejla","family":"Soudani","sequence":"first","affiliation":[{"name":"Animal Physiology Laboratory, Sfax Faculty of Sciences, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ibtissem Ben Amara","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, Sfax Faculty of Sciences, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afef","family":"Troudi","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, Sfax Faculty of Sciences, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanen","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, Sfax Faculty of Sciences, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahia","family":"Boudawara","sequence":"additional","affiliation":[{"name":"Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba","family":"Zeghal","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, Sfax Faculty of Sciences, University of Sfax, Tunisia,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,4]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1191\/096032701682693053"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1080\/15216540601156188"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.11.005"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00062-8"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00352-8"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1080\/15287398109530097"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100102418"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(71)90370-8"},{"key":"atypb10","first-page":"582","volume":"37","author":"Blacksmith Institute","year":"2007","journal-title":"Free Radical Biology and Medicine"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.007"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402003000300011"},{"key":"atypb13","first-page":"1","volume":"358","author":"Council of European Communities","year":"1986","journal-title":"Official Journal of the European Communities"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1191\/0960327105ht585oa"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.11.1967"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1080\/15287398609530908"},{"key":"atypb20","unstructured":"Gabe M. ( 1968) Techniques histologiques. Paris : Masson, 838-841."},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0167-7799(93)90158-6"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114485"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2004.02.025"},{"key":"atypb24","volume-title":"Monograph on the Evaluation of Carcinogenic Risk to Humans, Chromium, Nickel and Welding","author":"Iarc","year":"1990"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(98)00010-4"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2001.d01-92.x"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1159\/000136485"},{"key":"atypb28","first-page":"320","volume":"37","author":"Junaid M.","year":"1995","journal-title":"Veterinary and Human Toxicology"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03607-5"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1007\/s001289900194"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(96)03812-X"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00034-4"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2006.06.003"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/ehp.78241","volume":"24","author":"Makarov Y.","year":"1978","journal-title":"Environmental Health Perspectives"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1995.tb01548.x"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(19990501)79:6<815::AID-JSFA290>3.0.CO;2-P"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0756-2"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9270-z"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.088"},{"key":"atypb41","first-page":"206","volume":"7","author":"Pribluda LA","year":"1963","journal-title":"Dokl Akad Nauk Belrussk SSR"},{"key":"atypb42","first-page":"251","volume":"19","author":"Pritchard KA","year":"2000","journal-title":"Toxicology and Oncology"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.08.086"},{"key":"atypb44","volume-title":"M\u00e9thodes statistiques \u00e0 l\u2019usage des m\u00e9decins et des biologistes. [Statistical Methods for Doctor and Biologist\u2019s Use]","author":"Schwartz D.","year":"1963"},{"key":"atypb45","unstructured":"Shmitova LA ( 1978) The course of pregnancy in women engaged in the production of chromium and its compounds. Sverdlovsk 108-111 (Russian)."},{"key":"atypb46","first-page":"33","volume":"2","author":"Shmitova LA","year":"1980","journal-title":"Gig trud Prof Zabol"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.1.3.2887478"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00766-5"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.28.9"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.9.2382"},{"key":"atypb51","unstructured":"Tipton IH ( 1960) The distribution of trace metals in the human body . In: Seven MJ (ed.) Metal-Binding in Medicine. Philadelphia: Lippincott , 27."},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(89)90022-1"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(05)80191-4"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2006.08.003"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.2307\/3431145"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001004200"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.09.005"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233710395992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233710395992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:36:12Z","timestamp":1777667772000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233710395992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,4]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1177\/0748233710395992"],"URL":"https:\/\/doi.org\/10.1177\/0748233710395992","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,4]]}}}