{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:30:07Z","timestamp":1777923007014,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T00:00:00Z","timestamp":1319673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Osteoporosis represents a major public health problem through its association with fragility fractures, primarily of the hip, spine and distal forearm. The risk of osteoporosis increased in postmenopausal women due to decline in estrogen levels. Replicable hormone therapy is associated with undesirable side effects. Cod liver oil (CLO) is a rich source of docosahexaenoic acid eicosapentaenoic acid linolenic acid and vitamins A, E and D. In this study, the effect of CLO will be tested in the prevention of bone loss in the ovariectomized (OVX) female rats. One group of OVX rats ( n = 12) received an estrogen implantation at the time of operation and the second group was supplemented orally with CLO (200 \u03bcl\/kg body weight) daily for 8 weeks. At the end of the experiment, blood was analysed for serum calcium, phosphorous, bone-specific alkaline phosphatase, osteocalcin and estrogen and femur for calcium determination. Estrogen implantation as well as CLO supplementation in OVX rats increased the calcium level in femur as compared with sham rats ( p &lt; 0.05). It is concluded that supplementation of CLO have a positive effect on bone mineralization in rat, and this could offer a new strategy to avoid the side effects of replaceable hormonal therapy.<\/jats:p>","DOI":"10.1177\/0748233711412428","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T20:38:39Z","timestamp":1319747919000},"page":"387-392","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Modulatory effect of cod liver oil on bone mineralization in overiectomized female Sprague Dawley rats"],"prefix":"10.1177","volume":"28","author":[{"given":"Said S","family":"Moselhy","sequence":"first","affiliation":[{"name":"Biochemistry Department, King Abdualziz University, Jeddah, Saudi Arabia"},{"name":"Biochemistry Department, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman L","family":"Al-Malki","sequence":"additional","affiliation":[{"name":"Biochemistry Department, King Abdualziz University, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha A","family":"Kumosani","sequence":"additional","affiliation":[{"name":"Biochemistry Department, King Abdualziz University, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalaluddin A","family":"Jalal","sequence":"additional","affiliation":[{"name":"Biochemistry Department, King Abdualziz University, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"bibr1-0748233711412428","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V74613"},{"issue":"2","key":"bibr2-0748233711412428","doi-asserted-by":"crossref","first-page":"S565","DOI":"10.1002\/jbmr.5650081326","volume":"8","author":"Baylink D","year":"1993","journal-title":"Journal of Bone Mineral Research"},{"key":"bibr3-0748233711412428","first-page":"575","volume":"2","author":"Buck AC","year":"1994","journal-title":"Urolithiasis"},{"key":"bibr4-0748233711412428","first-page":"74","volume-title":"Health Effects of Polyunsaturated Fatty Acids in Seafoods","author":"Carlson SE","year":"1991"},{"key":"bibr5-0748233711412428","unstructured":"Claassen N (1996) The role of gamma-linolenic acid and eicosapentaenoic acid supplementation in intestinal calcium absorption and bone turnover. 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