{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:51:40Z","timestamp":1789642300729,"version":"4.0.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150\u00a0mg\/kg\/day, intraperitoneally [i.p.]) and CCl\n                    <jats:sub>4<\/jats:sub>\n                    toxication groups received a single injection of CCl\n                    <jats:sub>4<\/jats:sub>\n                    (1 ml\/kg, i.p.; CCl\n                    <jats:sub>4<\/jats:sub>\n                    and Va + CCl\n                    <jats:sub>4<\/jats:sub>\n                    groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO\n                    <jats:sub>2<\/jats:sub>\n                    and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    in rats.\n                  <\/jats:p>","DOI":"10.1177\/0748233711420472","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:49:56Z","timestamp":1318294196000},"page":"655-662","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Protective effect of vanillin against carbon tetrachloride (CCl\n                    <sub>4<\/sub>\n                    )-induced oxidative brain injury in rats"],"prefix":"10.1177","volume":"28","author":[{"given":"Mohamed","family":"Makni","sequence":"first","affiliation":[{"name":"Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia"},{"name":"Food Processing Department, ISET, Sidi Bouzid, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Chtourou","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Barkallah","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamadi","family":"Fetoui","sequence":"additional","affiliation":[{"name":"Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,10,10]]},"reference":[{"key":"bibr1-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"bibr2-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03833-I"},{"key":"bibr3-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2010.11.004"},{"key":"bibr4-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1515\/REVEH.2001.16.1.1"},{"key":"bibr5-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00029-6"},{"key":"bibr6-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00157-4"},{"key":"bibr7-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(71)90370-8"},{"key":"bibr8-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2008.07.003"},{"key":"bibr9-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(86)90260-5"},{"key":"bibr10-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/j.sigm.2006.03.001"},{"key":"bibr11-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(99)00090-3"},{"key":"bibr12-0748233711420472","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08006235"},{"key":"bibr13-0748233711420472","unstructured":"Council of European Communities (1986) Council instructions about the protection of living animals used in scientific investigations. 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