{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:19:37Z","timestamp":1792801177418,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T00:00:00Z","timestamp":1328659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>\n                    In the present work, the lethality percentiles including median lethal doses (LD\n                    <jats:sub>50<\/jats:sub>\n                    ), accumulation, distribution and toxicokinetics of aluminum in the liver, kidney, intestine, brain and serum of male albino rats, following a single oral administration were studied throughout 1, 3, 7, 14 and 28 days. The estimated LD\n                    <jats:sub>50<\/jats:sub>\n                    at 24 h was 3.45 g Al\/kg body weight (b.wt.). The utilized dose of Al was 1\/50 LD\n                    <jats:sub>50<\/jats:sub>\n                    (0.07 g Al\/kg b.wt.). Aluminum residues, in Al-treated rats, were significantly decreased in response to the experimental periods and were negatively correlated with time. In addition, the hepatic, renal, intestinal, brain and serum Al contents were significantly higher than the corresponding controls at all experimental periods, except the brain that showed significant depletion when compared with its corresponding control after 28 days. Kinetically, the highest average of Al area under concentration \u2212 time curves (AUC\n                    <jats:sub>total<\/jats:sub>\n                    , \u03bcg\/g day) and area under moment concentration \u2212 time curves (AUMC\n                    <jats:sub>total<\/jats:sub>\n                    , \u00b5g\/g day\n                    <jats:sup>2<\/jats:sup>\n                    ) recorded in the brain followed by kidney, serum, intestine and liver. The longest elimination half-life time ( t\n                    <jats:sub>1\/2<\/jats:sub>\n                    , day) and the mean residence time (MRT, day) were recorded in the brain followed by the liver, kidney, serum and intestine. On the other hand, the slowest clearance rates (Cls, L\/day) of Al, in order, were recorded in brain, kidney, serum, intestine and the liver. The elimination rate constant ( Lz, day\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    ) of Al from the brain was less than that in the intestine and serum was less than that in the liver and kidney. The computed maximum concentrations ( C\n                    <jats:sub>max<\/jats:sub>\n                    ) of Al in the intestine &gt; kidney &gt; serum &gt; brain &gt; liver were recorded after 3, 3.8, 2.2, 5.4 and 3.8 days, respectively. The computed starting concentration ( C\n                    <jats:sub>0<\/jats:sub>\n                    , \u03bcg) of Al in serum was higher than its level in the intestine followed by the brain, kidney and liver.\n                  <\/jats:p>","DOI":"10.1177\/0748233711432576","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T06:19:14Z","timestamp":1328768354000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Lethality, accumulation and toxicokinetics of aluminum in some tissues of male albino rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Sayed M","family":"Rawy","sequence":"first","affiliation":[{"name":"Faculty of Sciences and Arts, Khulais, King Abdul-Aziz University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal M","family":"Morsy","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majda M","family":"Elshibani","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,2,8]]},"reference":[{"key":"bibr1-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.11.335"},{"key":"bibr2-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.07.008"},{"key":"bibr3-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2010.11.007"},{"key":"bibr4-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90742-T"},{"key":"bibr5-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(95)00002-9"},{"key":"bibr6-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.09.014"},{"key":"bibr7-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2009.09.016"},{"key":"bibr8-0748233711432576","first-page":"363","volume":"65","author":"Ganrot PO","year":"1986","journal-title":"Environmental Health Perspectives"},{"key":"bibr9-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.05.004"},{"key":"bibr10-0748233711432576","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-207-43796"},{"key":"bibr11-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(86)90067-0"},{"key":"bibr12-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(92)90159-C"},{"key":"bibr13-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00059-B"},{"key":"bibr14-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.10.015"},{"issue":"4","key":"bibr15-0748233711432576","first-page":"244","volume":"40","author":"Jouhanneau P","year":"1993","journal-title":"Clinical Nephrology"},{"key":"bibr16-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00165-2"},{"key":"bibr17-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1080\/10937400701597766"},{"key":"bibr18-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1987.tb01752.x"},{"key":"bibr19-0748233711432576","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Institutes of Health","year":"1985"},{"key":"bibr20-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.01.032"},{"issue":"4","key":"bibr21-0748233711432576","first-page":"305","volume":"23","author":"Ondreicka R","year":"1966","journal-title":"British Journal of Industrial Medicine"},{"key":"bibr22-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.05.008"},{"key":"bibr23-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1177\/096032719801700602"},{"key":"bibr24-0748233711432576","unstructured":"Protasowicki M (1985) Comparison of techniques of fish sample preparation for heavy metals analysis by flam AAS. Proceedings 24th CSI, Garmisch-Partenkirchen 15\u201320 September 1985, 3, ThI 046, pp. 548\u2013549."},{"key":"bibr25-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(93)90203-B"},{"key":"bibr26-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2007.10.056"},{"key":"bibr27-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2007.09.010"},{"key":"bibr28-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00005-5"},{"key":"bibr29-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2009.06.010"},{"key":"bibr30-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52272-6.00715-7"},{"key":"bibr31-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2010.03.007"},{"key":"bibr32-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1990.tb00692.x"},{"key":"bibr33-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972620"},{"issue":"4","key":"bibr34-0748233711432576","first-page":"735","volume":"13","author":"Xu N","year":"1992","journal-title":"Neurotoxicology"},{"key":"bibr35-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600801009"},{"key":"bibr36-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90334-5"},{"key":"bibr37-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(88)80005-X"},{"key":"bibr38-0748233711432576","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(89)90118-X"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233711432576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0748233711432576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233711432576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:37:14Z","timestamp":1777667834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233711432576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,8]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1177\/0748233711432576"],"URL":"https:\/\/doi.org\/10.1177\/0748233711432576","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,8]]}}}