{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:30:42Z","timestamp":1777923042362,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The aim of this study was to evaluate the possible protective effects of Urtica dioica (UD) against liver damage in the common bile duct-ligated rats. A total of 24 male Sprague Dawley rats were divided into three groups, namely, control, bile duct ligation (BDL) and BDL\u00a0+\u00a0received UD groups, containing eight animals in each group. The rats in UD-treated groups were given UD oils (2\u00a0ml\/kg) once a day intraperitoneally for 2\u00a0weeks starting 3\u00a0days prior to BDL operation. The change demonstrating the bile duct proliferation and fibrosis in expanded portal tracts includes the extension of proliferated bile ducts into the lobules; inflammatory cell infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with UD attenuated alterations in liver histology. The \u03b1-smooth muscle actin, cytokeratin-positive ductular proliferation and the activity of terminal deoxynucleotidyl transferase dUTP nick end labeling in the BDL were observed to be reduced with the UD treatment. The data indicate that UD attenuates BDL-induced cholestatic liver injury, bile duct proliferation and fibrosis.<\/jats:p>","DOI":"10.1177\/0748233712445045","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:40:56Z","timestamp":1337042456000},"page":"838-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of\n                    <i>Urtica dioica<\/i>\n                    on liver damage induced by biliary obstruction in rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Serhat","family":"Oguz","sequence":"first","affiliation":[{"name":"Department of General Surgery, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Istanbul Medeniyet, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Erboga","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Ibis","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"bibr1-0748233712445045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.09.016"},{"key":"bibr2-0748233712445045","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700513"},{"key":"bibr30-0748233712445045","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260102"},{"key":"bibr4-0748233712445045","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(93)90107-6"},{"key":"bibr6-0748233712445045","unstructured":"Davis PH (ed) (1982) Flora of Turkey and the East Aegean Islands. 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