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In addition, the teratogenicity and embryotoxicity of maltitol was also investigated in rats. To reveal the genotoxicity and cytotoxicity of maltitol, rats were intraperitoneally administered 2.5, 5 and 10\u00a0g\/kg\u00a0body weight (bw) concentrations of maltitol for 6, 12 and 24\u00a0h treatment period. The pregnant females were intraperitoneally treated with 1, 2 and 4\u00a0g\/kg\u00a0bw\/day concentrations of maltitol during the first 7 days of gestation (first trimester) to investigate the teratogenicity of maltitol. The embryos were collected after killing the dams by cervical dislocation under ether anaesthesia on gestation day 19. Maltitol did not induce the CA and did not decrease the mitotic index in bone marrow cells of rats at all concentrations and treatment periods. In addition, maltitol was not teratogenic; however, it decreased the foetuses weight and at the highest dose (4\u00a0g\/kg\u00a0bw) caused growth retardation.<\/jats:p>","DOI":"10.1177\/0748233712446727","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:40:56Z","timestamp":1337042456000},"page":"935-943","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The genotoxic and teratogenic effects of maltitol in rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Semir","family":"Canimoglu","sequence":"first","affiliation":[{"name":"Department of Biology, Natural and Applied Science Institute, Cukurova University, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyyup","family":"Rencuzogullari","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Letters, Adiyaman University, Adiyaman, 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