{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:31:09Z","timestamp":1777923069653,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Sulfur dioxide (SO\n                    <jats:sub>2<\/jats:sub>\n                    ), which is used as food preservative in apricot sulfurization and several fabricated foods, is a common air pollutant. The aim of this study was to reveal the possible genotoxic effects of SO\n                    <jats:sub>2<\/jats:sub>\n                    using in vitro human lymphocytes. The different endpoints of genotoxicity: sister chromatid exchange (SCE), micronuclei (MN) tests and cell growth kinetics such as mitotic index (MI) and replication index (RI) were studied. The cells were treated with 0.1, 0.5 and 1.0\u00a0ppm concentrations of SO\n                    <jats:sub>2<\/jats:sub>\n                    . It was shown that SO\n                    <jats:sub>2<\/jats:sub>\n                    caused significant increases in the frequency of SCE and MN in the middle and high dosage groups and also induced mitotic delays and decreased MI and RI. In conclusion, the results have confirmed that SO\n                    <jats:sub>2<\/jats:sub>\n                    has potent mutagenicity and it can cause genetic damage leading to a malignancy.\n                  <\/jats:p>","DOI":"10.1177\/0748233712457441","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T23:49:03Z","timestamp":1345247343000},"page":"311-315","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Genotoxic effects of sulfur dioxide in human lymphocytes"],"prefix":"10.1177","volume":"30","author":[{"given":"Nihal","family":"Uren","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Genetics, Inonu University, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sengul","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Inonu University, 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