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The experiment was carried out for 8 weeks on 36 male rats that were divided equally into six groups. Group 1 was kept as normal control (given vehicle), while rats of group 2 were administered orally 200\u00a0mg\/kg\/day of celery oil. Groups 3 and 5 were orally given 500 and 1000\u00a0mg DEHP\/kg\/day, respectively. Groups 4 and 6 were treated with similar doses of DEHP as in groups 3 and 5 plus celery oil (200\u00a0mg\/kg\/day). Body and testicular weights, sperm parameters, serum hormones (testosterone, follicle-stimulating hormone, luteinizing hormone and estradiol), antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT)) and expression of cytochrome P450 aromatase (CYP19) messenger RNA (mRNA) were investigated at the end of 8th week. Treatment with DEHP alone resulted in a significant decrease in body and testicular weights, sperm parameters and serum hormone levels when compared with control. On the other hand, testicular antioxidant enzymes showed a significant dose-dependent increase. The expression of CYP19 mRNA was significantly reduced by increasing the doses of DEHP. Administration of celery oil along with DEHP partially prevented the decrease in body and testicular weights and enhanced epididymal sperm count, serum hormone levels and the expression of CYP19 mRNA along with diminution in the activities of SOD, GPx and CAT enzymes. The obtained results showed that the celery improved the testicular alterations induced by DEHP in albino rats.<\/jats:p>","DOI":"10.1177\/0748233712464808","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T20:36:40Z","timestamp":1353098200000},"page":"861-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Beneficial role of celery oil in lowering the di(2-ethylhexyl) phthalate-induced testicular damage"],"prefix":"10.1177","volume":"30","author":[{"given":"Naglaa K","family":"Madkour","sequence":"first","affiliation":[{"name":"Department of Zoology, Women College for Arts, Education and Science, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305977101"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.4.1252"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230390202335"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2004.04.002"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370204"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-35"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.048"},{"key":"e_1_3_2_10_1","unstructured":"Centers for Disease Control and Prevention (CDC) (2009) The 4th national report on human exposure to environmental chemicals. 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