{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:31:26Z","timestamp":1777923086148,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>\n                    This study describes the cytotoxic and phytotoxic activities of the crude extract of Heliotropium strigosum and its resultant fractions. In brine shrimp toxicology assays, profound cytotoxicity was displayed by ethyl acetate (LD\n                    <jats:sub>50<\/jats:sub>\n                    8.3\u00a0\u03bcg\/ml) and chloroform (LD\n                    <jats:sub>50<\/jats:sub>\n                    8.8\u00a0\u03bcg\/ml) fractions, followed by relatively weak crude methanolic extract of H. strigosum (LD\n                    <jats:sub>50<\/jats:sub>\n                    909\u00a0\u03bcg\/ml) and n-hexane fraction (LD\n                    <jats:sub>50<\/jats:sub>\n                    1000\u00a0\u03bcg\/ml). In case of phytotoxicity activity against Lemna acquinoctialis, highest phytotoxic effect was showed by ethyl acetate fraction (LD\n                    <jats:sub>50<\/jats:sub>\n                    91.0\u00a0\u03bcg\/ml), while chloroform fraction, plant crude extract and n-hexane, respectively, caused 50%, 30.76\u00a0\u00b1\u00a01.1% and 30.7\u00a0\u00b1\u00a01.1% inhibitory action at maximum concentration used, that is, 1000\u00a0\u03bcg\/ml. These data indicates that H. strigosum exhibits cytotoxic and phytotoxic potential, which explore its use as anticancer and herbicidal medicine. The ethyl acetate and chloroform fractions were more potent for the evaluated toxicity effects, thus recommended for isolation and identification of the active compounds.\n                  <\/jats:p>","DOI":"10.1177\/0748233712471706","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:06:37Z","timestamp":1360800397000},"page":"429-432","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytotoxic and phytotoxic actions of\n                    <i>Heliotropium strigosum<\/i>"],"prefix":"10.1177","volume":"31","author":[{"given":"Syed Majid","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan"},{"name":"Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif-ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan"},{"name":"Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhar-ul-Haq Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[{"name":"Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan"},{"name":"Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhat","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Malakand, Dir, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Barkatullah","sequence":"additional","affiliation":[{"name":"Department of Botany, University of Peshawar, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"bibr1-0748233712471706","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-99"},{"key":"bibr2-0748233712471706","unstructured":"Arvigo R, Balick M (1993) Rainforest Remedies. 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