{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:32:10Z","timestamp":1792330330719,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>The hypolipidemic effect of 10% fruit fibers in rats fed with high-fat diet (HFD) was evaluated. This study was conducted on a total of 50 male Albino rats divided into 10 equal groups fed with different types of dietary fruits. The feeding period lasted for 24 weeks. Fasting blood samples were collected and sera separated and subjected to lipid profile assay and atherogenic index. In addition, total antioxidant activity of different fruits was determined. The results obtained showed that pomegranate had higher content of antioxidants followed by apple, strawberry and guava compared with other fruits. Rats fed with 20% coconut oil showed a highly significant elevation in the levels of serum total cholesterol, low-density lipoprotein cholesterol and atherogenic factor while the level of high-density lipoprotein cholesterol was significantly decreased when compared with control rats. Histological examination revealed that there was a large lipid and cholesterol deposition in the livers of rats fed with HFD. The potential in lowering the levels of plasma total cholesterol and triglyceride is in the following order: pomegranate &gt; apple &gt; strawberry &gt; guava &gt; papaya &gt; mandarin and orange. Accumulation of hepatic lipid droplets was diminished when compared with the HFD group. Also, antiatherogenic is better than the untreated groups. Accordingly these hypolipidemic effects may be due to high-fiber content and antioxidant activity of these fruits.<\/jats:p>","DOI":"10.1177\/0748233712472526","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T00:46:10Z","timestamp":1357951570000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Hypolipidemic effect of fruit fibers in rats fed with high dietary fat"],"prefix":"10.1177","volume":"31","author":[{"given":"O.A.","family":"Esmael","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Faculty of Education and Home Economic, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Sonbul","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Faculty of Education and Home Economic, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Kumosani","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia"},{"name":"Experimental Biochemistry Unit, King Fahad Medical Research Center (KFMRC), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S","family":"Moselhy","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"bibr1-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00157-6"},{"key":"bibr2-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380020036007"},{"key":"bibr3-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.3.495"},{"key":"bibr4-0748233712472526","volume-title":"Official Methods of Analysis","author":"AOAC International","year":"1996","edition":"16"},{"key":"bibr5-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(01)00235-7"},{"key":"bibr6-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.32"},{"key":"bibr7-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1079\/095442200108729016"},{"key":"bibr8-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.013"},{"key":"bibr9-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1097\/00005082-200601000-00003"},{"key":"bibr10-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(97)00081-X"},{"key":"bibr11-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19960037"},{"key":"bibr12-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(02)00423-5"},{"key":"bibr13-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/23.5.882"},{"key":"bibr14-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2003.10.002"},{"key":"bibr15-0748233712472526","first-page":"1991s","volume":"54","author":"Nakayama T","year":"1994","journal-title":"Cancer Research"},{"key":"bibr16-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.10.070190.001053"},{"key":"bibr17-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.6.1210"},{"key":"bibr18-0748233712472526","first-page":"5","volume":"3","author":"O'Keefe JHJ","year":"1999","journal-title":"Cardiology Elderly"},{"key":"bibr19-0748233712472526","first-page":"393","volume-title":"Bogliolo-patologia","author":"Pereira FE","year":"2000","edition":"5"},{"key":"bibr20-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)04095-1"},{"key":"bibr21-0748233712472526","doi-asserted-by":"publisher","DOI":"10.1042\/bj3580547"},{"key":"bibr22-0748233712472526","volume-title":"Phory and Practical Histotechnology","author":"Sheehan D","year":"1980","edition":"2"},{"key":"bibr23-0748233712472526","unstructured":"Snedecor G, Cochran W (1980) Statistical Methods. 7th ed. 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