{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:42:26Z","timestamp":1788392546966,"version":"build-2803163510"},"reference-count":58,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>The aim of this study was to evaluate the effect of tocopherol on pleuritis-induced rats exposed to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD). Rats were treated with a single TCDD dose of 5 \u03bcg\/kg body weight (b.w.) and then for 3 weeks they were daily supplemented with tocopherol at a dose of 30 mg\/kg b.w. The inflammation was initiated by intrapleural injection of a single dose of 1% carrageenin solution in a volume of 0.15 ml. Changes in biochemical blood parameters were measured three times at the 24th, 72nd and 120th hour of pleuritis and the blood was collected from 20 animals of each group of rats (group with the control inflammation; group treated with TCDD and with control inflammation; group treated with TCDD, supplemented with tocopherol and with the inflammation). The following biochemical parameters were measured: tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-2, IL-4, IL-6, procollagen, telopeptide, fibrinogen, cholesterol, urea, creatinine, aspartate aminotransferase (AspAT) and alanine aminotransferase (AlAT). Daily supplementation of tocopherol caused significant changes in the level of TNF, IL-1, IL-4, IL-6, urea, creatinine, AspAT and AlAT. According to the results of these studies, we suggest that tocopherol supplementation in high doses could act as a protective treatment to improve liver metabolism.<\/jats:p>","DOI":"10.1177\/0748233713475497","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:06:37Z","timestamp":1360800397000},"page":"510-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of tocopherol on biochemical blood parameters in pleuritis-induced rats treated with 2,3,7,8-tetrachlorodibenzo-\n                    <i>p<\/i>\n                    -dioxin"],"prefix":"10.1177","volume":"31","author":[{"given":"Ireneusz","family":"Ca\u0142kosi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Rosi\u0144czuk-Tonderys","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Bronowicka-Szyde\u0142ko","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Wroclaw Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Dzierzba","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Wroclaw Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Bazan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Wroclaw Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Dobrzy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Majda","sequence":"additional","affiliation":[{"name":"Department of Diagnostics Laboratory, 4th Military Academic Hospital in Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Gamian","sequence":"additional","affiliation":[{"name":"Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Poland"},{"name":"Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"bibr1-0748233713475497","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2005.04264.x"},{"key":"bibr2-0748233713475497","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-008-9093-7"},{"key":"bibr3-0748233713475497","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2004.950305.x"},{"key":"bibr4-0748233713475497","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.08.008"},{"key":"bibr5-0748233713475497","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.06.004"},{"key":"bibr6-0748233713475497","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl100"},{"key":"bibr7-0748233713475497","unstructured":"Ca\u0142kosi\u0144ski I (2005) The course of experimentally induced acute pleuritis with use of nitrogranulogen (NTG) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 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