{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:31:58Z","timestamp":1777923118065,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T00:00:00Z","timestamp":1365465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. The experimental designed was based on Michaelis\u2013Menten parameters (apparent Michaelis constant (aKm) and apparent maximum velocity (aVm)) that estimate inhibition (%) as well as the type of inhibition (mechanism). The results showed marked inhibition of AchE by diazepam and the values of aKm and aVm were 65.5% and 52.63%, respectively. These values suggested a competitive type of antagonism for diazepam. Similar trend of antagonism was shown by phenobarbitone when it was subjected to the challenge of AchE with aKm and aVm values of 51.99% and 71.80%, respectively. It is concluded that diazepam and phenobarbitone exhibited prominent AchE attenuation apart from their well-established antidepressant activity, which could be more useful in related diseased conditions.<\/jats:p>","DOI":"10.1177\/0748233713480212","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:09:27Z","timestamp":1365552567000},"page":"920-923","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Attenuation of erythrocytic actylcholinesterase by antidepressants"],"prefix":"10.1177","volume":"31","author":[{"given":"Shafiq Ahmad","family":"Tariq","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Peshawar, Peshawar, Pakistan"},{"name":"Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan"},{"name":"Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Peshawar, Peshawar, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,9]]},"reference":[{"key":"bibr1-0748233713480212","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2009.02.004"},{"key":"bibr2-0748233713480212","doi-asserted-by":"publisher","DOI":"10.1042\/bj2120445"},{"key":"bibr3-0748233713480212","unstructured":"Harvey SC (1980) In: Goodman LS, Gilman A (eds) The Pharmacological Basis of Therapeutics 6th ed. 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