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Cells were pretreated with LCR, LCM, LCE, and LCL extracts (10\u201350\u00a0\u03bcg\/ml) of L. coronopifolia for 24\u00a0h and then ethanol was added and incubated further for 24\u00a0h. After the exposure, cell viability using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and neutral red uptake assays and morphological changes in HepG2 cells were studied. Pretreatment with various extracts of L. coronpifolia was found to be significantly effective in countering the cytotoxic responses of ethanol. Antioxidant properties of these L. coronopifolia extracts against reactive oxygen species (ROS) generation, lipid peroxidation (LPO), and glutathione (GSH) levels induced by ethanol were investigated. Results show that pretreatment with these extracts for 24\u00a0h significantly inhibited ROS generation and LPO induced and increased the GSH levels reduced by ethanol. The data from the study suggests that LCR, LCM, LCE, and LCL extracts of L. coronopifolia showed hepatoprotective activity against ethanol-induced damage in HepG2 cells. However, a comparative study revealed that the LCE extract was found to be the most effective and LCL the least effective. The hepatoprotective effects observed in the study could be associated with the antioxidant properties of these extracts of L. coronopifolia.<\/jats:p>","DOI":"10.1177\/0748233713483188","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T23:35:12Z","timestamp":1364513712000},"page":"727-737","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Hepatoprotective potential of\n                    <i>Lavandula coronopifolia<\/i>\n                    extracts against ethanol induced oxidative stress-mediated cytotoxicity in HepG2 cells"],"prefix":"10.1177","volume":"31","author":[{"given":"Nida Nayyar","family":"Farshori","sequence":"first","affiliation":[{"name":"College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtsam S","family":"Al-Sheddi","sequence":"additional","affiliation":[{"name":"College 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