{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:07:57Z","timestamp":1787018877886,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    This research work was planned to investigate the antioxidant potential of methanolic crude extract of\n                    <jats:italic toggle=\"yes\">Oxalis corniculata<\/jats:italic>\n                    (OCME) against lung injuries initiated by carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) in rats at histological and biochemical level. A total of 42 female Sprague Dawley rats were randomly distributed in to seven groups and each group comprised of six rats. Experiment was completed in 22 days (10 doses at alternate days). Group I was not treated (control rats), while group II was administered with vehicles (olive oil and dimethyl sulfoxide), groups III, IV, and V were treated with 1 ml kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    body weight (b.w.) of CCl\n                    <jats:sub>4<\/jats:sub>\n                    (20% in olive oil). Group III received only CCl\n                    <jats:sub>4<\/jats:sub>\n                    , whereas groups IV and V were administered with 100 and 200 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    b.w. of OCME, respectively. Group VI was administered with OCME (200 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    b.w.) alone. Group VII was treated with sylimarin (50 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    b.w.). CCl\n                    <jats:sub>4<\/jats:sub>\n                    enhanced the lipid peroxidation while reduced the glutathione in lung samples. Activities of antioxidant enzymes, catalase, peroxidase, superoxide dismutase, and glutathione-\n                    <jats:italic toggle=\"yes\">S<\/jats:italic>\n                    -transferase decreased in lung homogenates with CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Treatment of CCl\n                    <jats:sub>4<\/jats:sub>\n                    induced deleterious changes in the microanatomy of lungs by rupturing the alveolar septa, thickening of alveolar walls, and damaging the cells with subsequent collapse of blood vessels due to the accumulation of degenerated blood cells. OCME, dose dependently, prevented the alterations in these parameters. These results suggest that OCME protected the lungs due to its intrinsic properties by scavenging of free radicals generated by CCl\n                    <jats:sub>4<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/0748233713487245","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T23:23:17Z","timestamp":1372116197000},"page":"1243-1251","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Amelioration of carbon tetrachloride-induced pulmonary toxicity with\n                    <i>Oxalis corniculata<\/i>"],"prefix":"10.1177","volume":"31","author":[{"given":"Bushra","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Rashid","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseer Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233710373088"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00140-0"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209509065372"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.3923\/jpt.2011.337.348"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960004"},{"key":"e_1_3_2_7_1","volume-title":"Toxicological Profile for Carbon Tetrachloride (update)","author":"ATSDR","year":"2005","unstructured":"ATSDR (2005) Toxicological Profile for Carbon Tetrachloride (update). Atlanta, GA: US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry."},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)31922-1"},{"key":"e_1_3_2_9_1","volume-title":"Dictionary of Natural Compounds","author":"Buckingham J","year":"1999","unstructured":"Buckingham J (1999) Dictionary of Natural Compounds. London, UK: Chapman and Hall, CRC Press."},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(55)02300-8"},{"key":"e_1_3_2_11_1","first-page":"1","volume-title":"Cellular Injury and Cellular Death in Pathological Basis of Diseases","author":"Cortan RS","year":"1994","unstructured":"Cortan RS, Kumar V, Robbins SL (1994) Cellular Injury and Cellular Death in Pathological Basis of Diseases. 5th ed. Philadelphia, PA: WB Saunders Company, pp. 1\u201335.","edition":"5"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.29.040189.000245"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230326"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850150305"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.1996.11747079"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2001.843.845"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90131-2"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136485"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-008-9159-7"},{"key":"e_1_3_2_21_1","first-page":"130","article-title":"A modified spectrophotomateric assay of superoxide dismutase","volume":"21","author":"Kakkar P","year":"1984","unstructured":"Kakkar P, Das B, Viswanathan PN (1984) A modified spectrophotomateric assay of superoxide dismutase. Indian Journal of Biochemistry and Biophysics 21: 130\u2013132.","journal-title":"Indian Journal of Biochemistry and Biophysics"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769809065820"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.03.020"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.12.006"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-113"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.09.009"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.11.007"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.01.007"},{"key":"e_1_3_2_29_1","first-page":"437","volume-title":"Indian Medicinal Plants","author":"Kirtikar KR","year":"1975","unstructured":"Kirtikar KR, Basu BD (1975) Indian Medicinal Plants. 3rd ed., Volume 32. New Delhi, India: M.S. Periodical Experts, pp. 437.","edition":"3"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711420472"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-6-33"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10265-007-0132-x"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)44083-0"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.09.015"},{"key":"e_1_3_2_35_1","volume-title":"Edible Wild Plants","author":"Peterson LA","year":"1977","unstructured":"Peterson LA (1977) Edible Wild Plants. New York, NY: Houghton Mifflin Co."},{"key":"e_1_3_2_36_1","first-page":"72","article-title":"Phytochemical analysis and antibacterial activity of Oxalis corniculata, a known medicinal plant","author":"Raghavendra MP","year":"2006","unstructured":"Raghavendra MP, Satish S, Raveesha A (2006) Phytochemical analysis and antibacterial activity of Oxalis corniculata, a known medicinal plant. My Science 1: 72\u201378.","journal-title":"My Science"},{"key":"e_1_3_2_37_1","first-page":"444","article-title":"Actions of melatonin in the reduction of oxidative stress","volume":"7","author":"Reiter RJ","year":"2000","unstructured":"Reiter RJ, Tan D, Osuna C, Gitto E (2000) Actions of melatonin in the reduction of oxidative stress. Journal of Biological.Sciences 7: 444\u2013458.","journal-title":"Journal of Biological.Sciences"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711425076"},{"key":"e_1_3_2_39_1","first-page":"44","article-title":"Evaluation of antibacterial potentials of some plants against human pathogenic bacteria","volume":"2","author":"Satish S","year":"2008","unstructured":"Satish S, Raghavendra MP, Raveesha KA (2008) Evaluation of antibacterial potentials of some plants against human pathogenic bacteria. Advances in Biological Research 2: 44\u201348.","journal-title":"Advances in Biological Research"},{"key":"e_1_3_2_40_1","first-page":"58","article-title":"Antiimplantation activity and abortifacient activity of Oxalis corniculata (whole plant) in albino rats","volume":"1","author":"Sharangouda JP","year":"2007","unstructured":"Sharangouda JP, Patil SB (2007) Antiimplantation activity and abortifacient activity of Oxalis corniculata (whole plant) in albino rats. Nigerian Journal of Natural Product and Medicine 1: 58\u201360.","journal-title":"Nigerian Journal of Natural Product and Medicine"},{"key":"e_1_3_2_41_1","first-page":"193","volume-title":"Flowering plants of Chittoor District, Andhra Pradesh","author":"Shetty M","year":"2008","unstructured":"Shetty M, Sivaji K, Rao KT (2008) Flowering plants of Chittoor District, Andhra Pradesh. 1st ed. Tirupati, India: Student Offset Printer, pp. 193.","edition":"1"},{"key":"e_1_3_2_42_1","first-page":"444","article-title":"Wound healing activity of Oxalis corniculata whole plant extracts in rats","volume":"66","author":"Taranali AD","year":"2004","unstructured":"Taranali AD, Tipare SV, Kumar S (2004) Wound healing activity of Oxalis corniculata whole plant extracts in rats. Indian Journal of Pharmacuetical Science 66: 444\u2013446.","journal-title":"Indian Journal of Pharmacuetical Science"},{"issue":"2","key":"e_1_3_2_43_1","first-page":"21","article-title":"Pulmonary protective effects of curcumin against paraquat toxicity","volume":"66","author":"Venkatesan N","year":"2000","unstructured":"Venkatesan N (2000) Pulmonary protective effects of curcumin against paraquat toxicity. Life Sciences 66(2): 21\u201328.","journal-title":"Life Sciences"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00443-8"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090140"},{"key":"e_1_3_2_46_1","first-page":"1","article-title":"The protective effects of curcumin against carbon tetrachloride induced pulmonary injury in rats","volume":"13","author":"Zakaria I","year":"2004","unstructured":"Zakaria I, Khaliq IA, Selim ME (2004) The protective effects of curcumin against carbon tetrachloride induced pulmonary injury in rats. Egyptian Journal of Medical Laboratory Sciences 13: 1\u201315.","journal-title":"Egyptian Journal of Medical Laboratory Sciences"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00149-6"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233713487245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0748233713487245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233713487245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:09Z","timestamp":1777667949000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233713487245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1177\/0748233713487245"],"URL":"https:\/\/doi.org\/10.1177\/0748233713487245","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]}}}