{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:32:00Z","timestamp":1777923120877,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Ziprasidone, an atypical antipsychotic agent, has been shown to increase the corrected QT (QTc) interval in some patients. The aim of this study was to reveal the effects of metoprolol and diltiazem on ziprasidone drug-induced prolonged QTc interval. A total of 24 rats were equally divided into the following four groups: the first group was used as the control and received 1 mL\/kg saline; 3 mg\/kg ziprasidone and saline were administered to the second group; 3 mg\/kg ziprasidone and 1 mg\/kg metoprolol were administered to the third group and 3 mg\/kg ziprasidone and 2 mg\/kg diltiazem were administered to the fourth group. Two hours following application of the drugs, the QTc was calculated by performing electrocardiography in derivation (D)I. The duration of QTc interval was compared among the four groups. The mean QTc intervals were significantly increased in the third and fourth groups compared with the second group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.0005 and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.0001, respectively). The study demonstrated the effectiveness of metoprolol and diltiazem in the prevention of ziprasidone-induced elongation in the QTc interval. Both metoprolol and diltiazem may be considered in the prophylactic therapy of high-risk patients who are using ziprasidone.\n                  <\/jats:p>","DOI":"10.1177\/0748233713487249","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T22:32:09Z","timestamp":1367015529000},"page":"1152-1157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Metoprolol and diltiazem ameliorate ziprasidone-induced prolonged corrected QT interval in rats"],"prefix":"10.1177","volume":"31","author":[{"given":"Oytun","family":"Erbas","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Mugla University, Mugla, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.176.5.405"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960240112"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.3.212"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1989.tb10255.x"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0116"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.560114"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0408"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780330093011"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.156"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2003.012047"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.143.12.1518"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.08.010"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.170.2.186"},{"key":"e_1_3_2_15_1","first-page":"201","volume-title":"Lippincott\u2019s Illustrated Review: Pharmacology","author":"Harvey RA","year":"2009","unstructured":"Harvey RA, Champe PA, Flnkel R (2009) Antiarrhythmic drugs. 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(2010) Antipsychotic drugs: sudden cardiac death among elderly patients. 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