{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:35:21Z","timestamp":1785486921018,"version":"3.56.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Hepatic fibrosis is an important outcome of chronic liver injury and results in excess synthesis and accumulation of extracellular matrix (ECM) components. Phyllanthin (PLN) isolated from Phyllanthus amarus exhibits strong antioxidative property and protects HepG2 cells from carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )-induced experimental toxicity. The present study reports the antifibrotic potential of PLN. The in vivo inhibitory effect of PLN on CCl\n                    <jats:sub>4<\/jats:sub>\n                    -mediated lipid peroxidation and important profibrotic mediator transforming growth factor \u03b21 and on predominant ECM components collagen and fibronectin were also studied. The results show that PLN acts by suppressing the expression of inflammatory cytokine tumor necrosis factor-\u03b1 and prevents activation of nuclear factor-\u03baB in hepatic tissue. Our study highlights the molecular mechanism responsible for the antifibrotic efficacy of PLN.\n                  <\/jats:p>","DOI":"10.1177\/0748233714532996","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T20:20:07Z","timestamp":1399666807000},"page":"953-960","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Phyllanthin inhibits CCl\n                    <sub>4<\/sub>\n                    -mediated oxidative stress and hepatic fibrosis by down-regulating TNF-\u03b1\/NF-\u03baB, and pro-fibrotic factor TGF-\u03b21 mediating inflammatory signaling"],"prefix":"10.1177","volume":"32","author":[{"given":"Rajesh","family":"Krithika","sequence":"first","affiliation":[{"name":"Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasavan","family":"Jyothilakshmi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramtej Jayaram","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"bibr1-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17552"},{"key":"bibr2-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2001-7-826"},{"key":"bibr3-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1128(199807)18:4<225::AID-MED2>3.0.CO;2-X"},{"key":"bibr4-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020894"},{"key":"bibr5-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.01.003"},{"key":"bibr6-0748233714532996","first-page":"237","volume":"117","author":"Constandinou C","year":"2005","journal-title":"Methods in Molecular Medicine"},{"key":"bibr7-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007105"},{"key":"bibr8-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"bibr9-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222700502"},{"key":"bibr10-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90519-2"},{"key":"bibr11-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104794200"},{"key":"bibr12-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh120"},{"key":"bibr13-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.109"},{"key":"bibr14-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.9.1491"},{"issue":"4","key":"bibr15-0748233714532996","first-page":"439","volume":"66","author":"Krithika R","year":"2009","journal-title":"Acta Poloniae Pharmaceutica Drug Research"},{"issue":"5","key":"bibr16-0748233714532996","first-page":"579","volume":"66","author":"Krithika R","year":"2009","journal-title":"Acta Poloniae Pharmaceutica Drug Research"},{"key":"bibr17-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.06.014"},{"key":"bibr18-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/S0973-6883(11)60123-0"},{"key":"bibr19-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X06003679"},{"key":"bibr20-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095906"},{"key":"bibr21-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"bibr22-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.09.015"},{"key":"bibr23-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.891"},{"key":"bibr24-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"bibr25-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000017365.18894.D3"},{"key":"bibr26-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(00)00004-2"},{"key":"bibr27-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1078\/0171-9335-00182"},{"key":"bibr28-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2800040507"},{"key":"bibr29-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394596-9.00011-1"},{"key":"bibr30-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(85)90026-1"},{"key":"bibr31-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1002\/pca.936"},{"issue":"3","key":"bibr32-0748233714532996","first-page":"309","volume":"65","author":"Venkatesan P","year":"2003","journal-title":"Indian Journal Pharmaceutical Sciences"},{"key":"bibr33-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2004.02.007"},{"key":"bibr34-0748233714532996","first-page":"235","volume-title":"The Methodology of Connective Tissue Research","author":"Woessner JF","year":"1976"},{"key":"bibr35-0748233714532996","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00474.2002"},{"key":"bibr36-0748233714532996","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i1.77"}],"container-title":["Toxicology and Industrial Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233714532996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0748233714532996","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748233714532996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:39:57Z","timestamp":1777667997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0748233714532996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/0748233714532996"],"URL":"https:\/\/doi.org\/10.1177\/0748233714532996","relation":{},"ISSN":["0748-2337","1477-0393"],"issn-type":[{"value":"0748-2337","type":"print"},{"value":"1477-0393","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,9]]}}}