{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:09:30Z","timestamp":1792289370419,"version":"4.4.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    Treatment of rats with carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ; 2 ml\/kg body weight) once a week for 12 weeks caused a significant decrease in serum levels of testosterone, luteinizing hormone, and follicle-stimulating hormone. These decreases in sex hormones were reduced with Physalis peruviana L. (Cape gooseberry) juice supplementation. In addition, testicular activity of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione- S-transferase suppressed with CCl\n                    <jats:sub>4<\/jats:sub>\n                    were elevated after P. peruviana juice supplements. P. peruviana juice supplementation significantly increased the testicular glutathione and significantly decreased the level of lipid peroxidation and the nitric oxide production compared with the CCl\n                    <jats:sub>4<\/jats:sub>\n                    group. In addition, the decline in the activity of antioxidant enzymes after CCl\n                    <jats:sub>4<\/jats:sub>\n                    was ameliorated by P. peruviana. Moreover, degeneration of germ and Leydig cells along with deformities in spermatogenesis induced after CCl\n                    <jats:sub>4<\/jats:sub>\n                    injections were prevented with the supplementation of P. peruviana juice. Furthermore, P. peruviana juice attenuated CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced apoptosis in testes tissue by inhibition of caspase-3 activity. The results clearly demonstrate that P. peruviana juice augments the antioxidants defense mechanism against CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced reproductive toxicity and provides evidence that the juice may have a therapeutic role in free radical-mediated diseases and infertility.\n                  <\/jats:p>","DOI":"10.1177\/0748233714545502","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T03:01:08Z","timestamp":1408676468000},"page":"1064-1073","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Prevention of carbon tetrachloride (CCl\n                    <sub>4<\/sub>\n                    )-induced toxicity in testes of rats treated with\n                    <i>Physalis peruviana<\/i>\n                    L. fruit"],"prefix":"10.1177","volume":"32","author":[{"given":"Ahmed E","family":"Abdel Moneim","sequence":"first","affiliation":[{"name":"Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"bibr2a-0748233714545502","doi-asserted-by":"crossref","unstructured":"Abdel Moneim AE, Bauomy AA, Diab MM, (2014) The Protective Effect of\n                      Physalis peruviana\n                      L. Against Cadmium-Induced Neurotoxicity in Rats. Biological Trace Element Research. Published online, 15 July 2014, doi:10.1007\/s12011-014-0066-9.","DOI":"10.1007\/s12011-014-0066-9"},{"key":"bibr1-0748233714545502","first-page":"1038","volume":"9","author":"Abdel Moneim AE","year":"2012","journal-title":"Life Scince Journal"},{"key":"bibr2-0748233714545502","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-012-0218-3"},{"key":"bibr3-0748233714545502","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-010-8882-z"},{"key":"bibr4-0748233714545502","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"bibr5-0748233714545502","doi-asserted-by":"crossref","unstructured":"Al-Olayan E, Elkhadragy MF, Aref AM, (2014a) The potential protective effect of\n                      Physalis peruviana\n                      L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression. Oxidative Medicine and Cellular Longevity 2014; 2014. 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