{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:14:43Z","timestamp":1787886883680,"version":"build-2784847793"},"reference-count":65,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Ind Health"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>This study aims to evaluate the possible ameliorative effect of earthworm ( Allolobophora caliginosa) extract (EE) against silicon dioxide nanoparticles (SiNPs)-induced liver injury in male albino rats. The effectiveness of EE was compared with silymarin as a standard hepatoprotective drug. The present work demonstrates the antioxidant activity of EE by 1,1-diphenyl-2-picrylhydrazyl assay. Administration of SiNPs, for 15 consecutive days, caused changes in most of the biochemical parameters, namely, serum aminotransferase enzymes activities (alanine transaminase and aspartate transaminase), alkaline phosphatase activity, total protein, total and direct bilirubin level, malondialdehyde, glutathione reduced, catalase, superoxide dismutase, glutathione reductase, and glutathione peroxidase. In addition, administration of SiNPs induced changes in liver tissue architecture. Administration of EE, for subsequent 30 days, to SiNPs exposure demonstrated significant ameliorative effects on nearly all the studied parameters, and such effects were compatible with those of silymarin. In addition, the administration of EE repairs, to some extent, the abnormal architecture of the liver tissue induced by SiNPs.<\/jats:p>","DOI":"10.1177\/0748233714561075","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T03:26:31Z","timestamp":1419909991000},"page":"1358-1372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Ameliorative effect of\n                    <i>Allolobophora caliginosa<\/i>\n                    extract on hepatotoxicity induced by silicon dioxide nanoparticles"],"prefix":"10.1177","volume":"32","author":[{"given":"Shimaa A","family":"Sadek","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel M","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Marzouk","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"bibr1-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"bibr2-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.10.016"},{"key":"bibr3-0748233714561075","first-page":"61","volume":"5","author":"Ahmad M","year":"1992","journal-title":"Journal of Islamic Academy of Sciences"},{"key":"bibr4-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.07.010"},{"key":"bibr5-0748233714561075","first-page":"699","volume":"23","author":"Anuradha CV","year":"1995","journal-title":"Medical Science Research"},{"key":"bibr6-0748233714561075","volume-title":"Standard Terminology Relating to Nanotechnology","author":"American Society for Testing and Materials (ASTM)","year":"2006"},{"key":"bibr7-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-009-9740-9"},{"key":"bibr8-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B0720194"},{"key":"bibr9-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10327"},{"key":"bibr10-0748233714561075","doi-asserted-by":"publisher","DOI":"10.1159\/000459586"},{"key":"bibr11-0748233714561075","first-page":"882","volume":"61","author":"Beutler E","year":"1963","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"bibr12-0748233714561075","unstructured":"Block RJ, Durrum EL, Zweig G (1958) Annual of Paper Chromatography and Paper Electrophoresis. 2nd ed. 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